ArticleCritical care research and practice2019
Using pCO
Article in Critical care research and practice, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Renal Veno-Arterial Carbon Dioxide Gap Fails to Detect Renal Medulla Microcirculatory Changes in a Large Animal Model of Sepsis-Associated Acute Kidney Injury.Shock (Augusta, Ga.) · 2026Article
- The metabolic response to stress in critical illness: updated review on the pathophysiological mechanisms, consequences, and therapeutic implications.Annals of intensive care · 2025Review
- Clinical applications of blood gas analysis: a comparative review of arterial and venous blood gas monitoring in critical care.Acute and critical care · 2025Article
- Prehospital blood gas analyses in acute patients treated by a ground-based physician-manned emergency unit: a cohort study.Scandinavian journal of trauma, resuscitation and emergency medicine · 2023Article
- Venous Minus Arterial Carbon Dioxide Gradients in the Monitoring of Tissue Perfusion and Oxygenation: A Narrative Review.Medicina (Kaunas, Lithuania) · 2023Review
- Evaluation of respiratory exchange ratio (RER) for predicting postoperative outcomes in elderly patients undergoing oncological resection for gastrointestinal malignancies - A prospective cohort study.Indian journal of anaesthesia · 2023Article
- Treatment of Hyperlactatemia in Acute Circulatory Failure Based on COFrontiers in cardiovascular medicine · 2022Article
- Pathophysiology and clinical implications of the veno-arterial PCOCritical care (London, England) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThere is an inverse relationship between cardiac output and the central venous-arterial difference of partial pressures of carbon dioxide (pCO
methodsWe performed a structured review of the literature enlightening the physiological background. Next, we retrospectively selected a series of case reports of nonseptic critically ill patients with elevated lactate, in whom both arterial and central venous blood gases were simultaneously measured and the diagnosis of either type A or type B hyperlactataemia was conclusively known. In these cases, we calculated venous-arterial CO
resultsBased on available physiological data, pCO
conclusionPhysiological rationale and a small case series are consistent with the hypothesis that low pCO
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.