Evidence map›Paper›PMID 31885806›Full record

ArticleOxidative medicine and cellular longevity2019

HIV-1 Reverse Transcriptase Promotes Tumor Growth and Metastasis Formation via ROS-Dependent Upregulation of Twist.

Ekaterina Bayurova, Juris Jansons, Dace Skrastina, Olga Smirnova, Dzeina Mezale, Anastasia Kostyusheva, Dmitry Kostyushev, Stefan Petkov, Philip Podschwadt, Vladimir Valuev-Elliston and 18 more

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 10 institutions in 3 countries.

Ekaterina BayurovaNF Gamaleya Research Center of Epidemiology and Microbiology, Moscow, Russia.ORCID https://orcid.org/0000-0002-6160-2203
Juris JansonsDepartment of Pathology, Riga Stradins University, Riga, Latvia.
Dace SkrastinaDepartment of Pathology, Riga Stradins University, Riga, Latvia.
Olga SmirnovaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.ORCID https://orcid.org/0000-0002-4980-9754
Dzeina MezaleDepartment of Pathology, Riga Stradins University, Riga, Latvia.
Anastasia KostyushevaNational Medical Research Center for Tuberculosis and Infectious Diseases, Moscow, Russia.
Dmitry KostyushevNational Medical Research Center for Tuberculosis and Infectious Diseases, Moscow, Russia.
Stefan PetkovDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Philip PodschwadtDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Vladimir Valuev-EllistonEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.ORCID https://orcid.org/0000-0003-0365-570X
Sviataslau SasinovichDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Sergey KorolevChemistry Department and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.ORCID https://orcid.org/0000-0003-2278-4451
Per WarholmScience for Life Laboratory, Stockholm University, Stockholm, Sweden.
Anastasia LatanovaNF Gamaleya Research Center of Epidemiology and Microbiology, Moscow, Russia.ORCID https://orcid.org/0000-0002-2260-6551
Elizaveta StarodubovaNF Gamaleya Research Center of Epidemiology and Microbiology, Moscow, Russia.ORCID https://orcid.org/0000-0003-2183-0858
Amir TukhvatulinNF Gamaleya Research Center of Epidemiology and Microbiology, Moscow, Russia.ORCID https://orcid.org/0000-0001-8506-2339
Oleg LatyshevNF Gamaleya Research Center of Epidemiology and Microbiology, Moscow, Russia.
Renat SelimovRussian State Center for Quality and Standardization of Veterinary Drugs and Feed (VGNKI), Moscow, Russia.
Pavel MetalnikovRussian State Center for Quality and Standardization of Veterinary Drugs and Feed (VGNKI), Moscow, Russia.
Alexander KomarovRussian State Center for Quality and Standardization of Veterinary Drugs and Feed (VGNKI), Moscow, Russia.
Olga IvanovaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.ORCID https://orcid.org/0000-0002-3673-4714
Tatiana GorodnichevaEvrogen, Moscow, Russia.
Sergey KochetkovEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.ORCID https://orcid.org/0000-0002-7443-6961
Marina GottikhChemistry Department and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
Ilze StrumfaDepartment of Pathology, Riga Stradins University, Riga, Latvia.
Alexander IvanovEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.ORCID https://orcid.org/0000-0002-5659-9679
Ilya GordeychukNF Gamaleya Research Center of Epidemiology and Microbiology, Moscow, Russia.
Maria IsaguliantsNF Gamaleya Research Center of Epidemiology and Microbiology, Moscow, Russia.ORCID https://orcid.org/0000-0001-9382-2254
Engelhardt Institute of Molecular Biology · RUAll-Russian State Scientific Research Institute for Control, Standardization and Certification of Veterinary Preparations · RUKarolinska Institutet · SERussian Academy of Sciences · RUCentral Scientific Research Institute of Tuberculosis Russian Academy of Medical Sciences · RUGamalei Institute of Epidemiology and Microbiology · RULatvian Biomedical Research and Study Centre · LVLomonosov Moscow State University · RURiga Stradiņš University · LVStockholm University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HIV-induced immune suppression results in the high prevalence of HIV/AIDS-associated malignancies including Kaposi sarcoma, non-Hodgkin lymphoma, and cervical cancer. HIV-infected people are also at an increased risk of "non-AIDS-defining" malignancies not directly linked to immune suppression but associated with viral infections. Their incidence is increasing despite successful antiretroviral therapy. The mechanism behind this phenomenon remains unclear. Here, we obtained daughter clones of murine mammary gland adenocarcinoma 4T1luc2 cells expressing consensus reverse transcriptase of HIV-1 subtype A FSU_A strain (RT_A) with and without primary mutations of drug resistance. In

Indexed as

AdenocarcinomaAnimalsBreast NeoplasmsCarcinogenesisCell Growth ProcessesCell Line, TumorEpithelial-Mesenchymal TransitionFemaleHIV-1HIV InfectionsHIV Reverse TranscriptaseHumansMammary Neoplasms, ExperimentalMiceMice, Inbred BALB CMutationHIV Reverse TranscriptaseReactive Oxygen Speciesreverse transcriptase, Human immunodeficiency virus 1Twist-Related Protein 1

Identifiers

PMID31885806
PMCPMC6915010
OpenAlexW2994505756

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.