Evidence map›Paper›PMID 31885803›Full record

ArticleOxidative medicine and cellular longevity2019

Cathepsin B pH-Dependent Activity Is Involved in Lysosomal Dysregulation in Atrophic Age-Related Macular Degeneration.

Audrey Voisin, Christelle Monville, Alexandra Plancheron, Emile Béré, Afsaneh Gaillard, Nicolas Leveziel

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Stem cell therapy in retinal diseases.Neural regeneration research · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Audrey VoisinUniversity of Poitiers, Laboratoire de Neurosciences Expérimentales et Cliniques, Equipe Thérapie Cellulaire dans les Pathologies Cérébrales, Poitiers F-86073, France.ORCID https://orcid.org/0000-0002-9766-5759
Christelle MonvilleINSERM, UMR861, I-Stem, AFM, Genopole Campus 1, Evry F-91030, France.ORCID https://orcid.org/0000-0003-1256-5140
Alexandra PlancheronINSERM, UMR861, I-Stem, AFM, Genopole Campus 1, Evry F-91030, France.
Emile BéréUniversity of Poitiers, Laboratoire de Neurosciences Expérimentales et Cliniques, Equipe Thérapie Cellulaire dans les Pathologies Cérébrales, Poitiers F-86073, France.
Afsaneh GaillardUniversity of Poitiers, Laboratoire de Neurosciences Expérimentales et Cliniques, Equipe Thérapie Cellulaire dans les Pathologies Cérébrales, Poitiers F-86073, France.
Nicolas LevezielUniversity of Poitiers, Laboratoire de Neurosciences Expérimentales et Cliniques, Equipe Thérapie Cellulaire dans les Pathologies Cérébrales, Poitiers F-86073, France.
Inserm · FRUniversité de Poitiers · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age-related macular degeneration (AMD) is characterized by retinal pigment epithelial (RPE) cell dysfunction beginning at early stages of the disease. The lack of an appropriate

Indexed as

AtrophyCathepsin BCell DeathCells, CulturedCellular SenescenceFerric CompoundsHumansHydrogen-Ion ConcentrationInduced Pluripotent Stem CellsLysosomesMacular DegenerationNitrilotriacetic AcidOxidative StressProteolysisReactive Oxygen SpeciesRetinal Pigment EpitheliumCathepsin BFerric Compoundsferric nitrilotriacetateNitrilotriacetic AcidReactive Oxygen Species

Identifiers

PMID31885803
PMCPMC6925809
OpenAlexW2993769964

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.