Evidence map›Paper›PMID 31885577›Full record

ArticleJournal of oncology2019

Expression Analysis of the Mediators of Epithelial to Mesenchymal Transition and Early Risk Assessment of Therapeutic Failure in Laryngeal Carcinoma.

Nora Kariche, Nabila Moulaï, Leila-Sarah Sellam, Samir Benyahia, Wahiba Ouahioune, Djamel Djennaoui, Chafia Touil-Boukoffa, Mehdi Bourouba

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Nora KaricheDepartment of Cell and Molecular Biology, Team Cytokines and Nitric Oxide Synthases. Faculty of Biology, University Houari Boumediene USTHB, Algiers, Algeria.ORCID https://orcid.org/0000-0002-8877-2691
Nabila MoulaïCentral Laboratory for Anatomopathology, Frantz Fanon Hospital, Blida, Algeria.
Leila-Sarah SellamDepartment of Cell and Molecular Biology, Team Cytokines and Nitric Oxide Synthases. Faculty of Biology, University Houari Boumediene USTHB, Algiers, Algeria.
Samir BenyahiaOto-Rhyno-laryngology Department, Mustapha Pacha Hospital, Algiers, Algeria.
Wahiba OuahiouneCentral Laboratory for Anatomopathology, Frantz Fanon Hospital, Blida, Algeria.
Djamel DjennaouiOto-Rhyno-laryngology Department, Mustapha Pacha Hospital, Algiers, Algeria.
Chafia Touil-BoukoffaDepartment of Cell and Molecular Biology, Team Cytokines and Nitric Oxide Synthases. Faculty of Biology, University Houari Boumediene USTHB, Algiers, Algeria.
Mehdi BouroubaDepartment of Cell and Molecular Biology, Team Cytokines and Nitric Oxide Synthases. Faculty of Biology, University Houari Boumediene USTHB, Algiers, Algeria.ORCID https://orcid.org/0000-0002-2304-5899
University of Sciences and Technology Houari Boumediene · DZHôpital Mustapha Pacha · DZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Laryngeal squamous cell carcinoma (LSCC) is an aggressive malignancy which lacks early predictors of prognosis. Here, we hypothesized that expression and prognostic characterization of the critical mediators of epithelial to mesenchymal transition (EMT) may provide key information in this regard. Linear regression and multiple correspondence analyses were performed on immunohistochemical data obtained from 20 invasive tumors. Principal component and unsupervised hierarchical clustering were used to analyze the dataset patterns associating with LSCC metastatic profile. Survival and death risk assessments were performed using Kaplan-Meier and hazard ratio tests. Data mining analysis using CHAID decision tree and logistic regression analysis was applied to define the predictive value of the risk factors of tumor aggressiveness. Our analyses showed, that in invasive LSCC tumors, cells associating with a mesenchymal profile were likely to exhibit enhanced NOS2, TGF-

Identifiers

PMID31885577
PMCPMC6926423
OpenAlexW2994309332

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.