ArticleInternational journal of endocrinology2019
A Mechanism Exploration of Metabolic Syndrome Causing Nodular Thyroid Disease.
Article in International journal of endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- The Relationship and Gender Disparity Between Thyroid Nodules and Metabolic Syndrome Components Based on a Recent Nationwide Cross-Sectional Study and Meta-Analysis.Frontiers in endocrinology · 2021Pooled it
- Association of Central Obesity and Diabetes with Thyroid Nodules: A 3.2-year Prospective Study in Chinese Adults.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Adiposity Is Associated with a Higher Risk of Thyroid Malignancy in Patients with Hashimoto's Thyroiditis.Diagnostics (Basel, Switzerland) · 2025Article
- Adiposity is associated with a higher number of thyroid nodules and worse fine-needle aspiration outcomes.European thyroid journal · 2025Article
- The Correlation between Elevated HDL-Cholesterol, Body Mass Index, and Presence of Thyroid Nodules: A Retrospective Analysis.Journal of clinical medicine · 2023Article
- Association between Metabolic Syndrome and Leukocytes: Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Review
- Thyroid Nodules and Obesity.Life (Basel, Switzerland) · 2023Review
- The association of uric acid with the development of thyroid nodules: a retrospective cohort study.BMC endocrine disorders · 2022Review
- Glucose Metabolism Derangements and Thyroid Nodules: Does Sex Matter?Journal of personalized medicine · 2022Article
- Association Between Body Mass Index and Thyroid Function in Euthyroid Chinese Adults.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Presence of Metabolic Syndrome and Thyroid Nodules in Subjects with Colorectal Polyps.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Geographical influences on thyroid abnormalities in adult population from iodine-replete regions: a cross-sectional study.Scientific reports · 2021Article
- Thyroid and Pseudothyroid Dysfunction as a Cause That is Promoting the Relapse of Benign Focal Thyroid Pathology.Journal of medicine and lifeArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMetabolic syndrome (MS) and its components have been demonstrated to facilitate the prevalence of thyroid nodules (TNs). The underlying pathogenesis needs to be elucidated.
methodsA total of 2722 subjects, who underwent health checkup in our institute from December 2014 to November 2018, were retrospectively and randomly collected. After exclusion, 2068 subjects were chosen, and their anthropic and clinical data were collected.
resultsAfter matching age, gender, uric acid (UA), and creatinine (Cr) by propensity score matching (PSM), subjects with MS had higher prevalence of TNs than those without MS, as well as higher thyroid-stimulating hormone (TSH) and inflammatory levels, indicated by the higher white blood cell (WBC), lymphocyte (LY), and monocyte/high-density lipoprotein (Mo/HDL). After matching age, gender, UA, Cr, TSH, free triiodothyronine (FT3), thyroxine (FT4), WBC, NE, LY, Mo, NE/LY, LY/Mo, and Mo/HDL by PSM, no significant difference of the prevalence of TNs was found between MS and non-MS groups. Step logistic regression suggested glucose intolerance (GI), among all the components of MS, was an independent impact factor of TNs and was considered to contribute most to the formation of TNs. The prevalence of TNs was higher in the GI group after matching age, gender, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood sugar (FBS), UA, Cr, triglyceride (TG), cholesterol (CHOL), HDL, and low-density lipoprotein (LDL).
conclusionsPatients with MS have a higher prevalence of TNs, probably due to the elevated TSH and inflammatory levels
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.