ArticleInternational journal of endocrinology2019
The Cerebellum Posterior Lobe Associates with the Exophthalmos of Primary Hyperthyroidism: A Resting-State fMRI Study.
Article in International journal of endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 20 citations in OpenAlex.
- Effect of Regional Brain Activity Following Repeat Transcranial Magnetic Stimulation in SCA3: A Secondary Analysis of a Randomized Clinical Trial.Cerebellum (London, England) · 2024Trial
- Detecting altered spontaneous activities of different brain areas in diabetic vitreous hemorrhage patients: a magnetic resonance imaging study.International journal of ophthalmology · 2026Article
- Aberrant brain functional connectivity in patients with dysthyroid optic neuropathy: a resting-state fMRI study.Frontiers in neuroscience · 2026Article
- Retinal microvasculature alteration in patients with acute pancreatitis: an observational OCTA study.European journal of medical research · 2025Observational
- Rescue of myocytes and locomotion throughMolecular therapy. Methods & clinical development · 2024Article
- Electroacupuncture modulates abnormal brain connectivity after ischemia reperfusion injury in rats: A graph theory-based approach.Brain and behavior · 2024Article
- Functional decoding and meta-analytic connectivity modeling in thyroid-associated ophthalmopathy.Heliyon · 2024Article
- Functional connectivity alterations in the thalamus among patients with bronchial asthma.Frontiers in neurology · 2024Article
- Spontaneous changes in brain network centrality in patients with pathological myopia: A voxel-wise degree centrality analysis.CNS neuroscience & therapeutics · 2023Article
- Increased brain iron in patients with thyroid-associated ophthalmopathy: a whole-brain analysis.Frontiers in endocrinology · 2023Article
- Abnormal regional spontaneous neural activity and functional connectivity in thyroid-associated ophthalmopathy patients with different activity: a resting-state fMRI study.Frontiers in neurology · 2023Article
- Abnormal Fractional Amplitude of Low Frequency Fluctuation Changes in Patients With Dry Eye Disease: A Functional Magnetic Resonance Imaging Study.Frontiers in human neuroscience · 2022Article
- Article
- Brain Functional Connectivity Changes in Patients with Acute Eye Pain: A Resting-State Functional Magnetic Resonance Imaging (fMRI) Study.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Altered brain network centrality in middle-aged patients with retinitis pigmentosa: A resting-state functional magnetic resonance imaging study.Brain and behavior · 2021Article
- Altered Static and Dynamic Interhemispheric Resting-State Functional Connectivity in Patients With Thyroid-Associated Ophthalmopathy.Frontiers in neuroscience · 2021Article
- Altered Brain Network Centrality in Patients with Adult Strabismus with Amblyopia: A Resting-State Functional Magnetic Resonance Imaging (fMRI) Study.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExophthalmos occurs in patients with primary hyperthyroidism. There were few studies about the changes of brain functional networks of patients with exophthalmos of primary hyperthyroidism (EOPH). However, differences in spontaneous brain activity in patients with EOPH remain unclear.
objectiveThis study explored alterations in the brain functional networks of patients with EOPH using a voxel-wise degree centrality (DC) method.
methodsA total of 20 patients with EOPH (8 men and 12 women) were enrolled. In addition, 20 patients with primary hyperthyroidism without exophthalmos, matched in age, sex, and education status, were enrolled as a control group. The Hospital Anxiety and Depression Scale was used to assess the anxiety and depression status of participants. All participants were examined using resting-state functional MRI. Changes in spontaneous brain activity were investigated using the DC method. To distinguish between the DC values of the patients with EOPH and those of the control group, we analyzed the receiver operating characteristic (ROC) curve. The interrelationships between the DC values and clinical variables in the patients with EOPH were evaluated using Pearson's correlation coefficient.
resultsPatients with EOPH exhibited notably lower DC values in the cerebellum posterior lobe than the control group. In addition, there were negative correlations between the anxiety scores (AS) and the depression scores (DS) and DC values of the cerebellum posterior lobe. The ROC curve analysis of the cerebellum posterior lobe demonstrated that the area under the curve method had a high diagnostic accuracy.
conclusionsOur study was the first, to our knowledge, to explore changes in the brains of patients with EOPH using the DC method. The DC value was significantly different in the cerebellum posterior lobe in patients with EOPH, indicating that the cerebellum posterior lobe is associated with EOPH.
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