ArticleNeural plasticity2019
Amygdala Changes in Chronic Insomnia and Their Association with Sleep and Anxiety Symptoms: Insight from Shape Analysis.
Article in Neural plasticity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Distinct Convergent Brain Alterations in Sleep Disorders and Sleep Deprivation: A Meta-Analysis.JAMA psychiatry · 2025Pooled it
- Longitudinal effects of physical activity on sleep in association with hippocampal-amygdala subfield structure and functional connectivity in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Trial
- Skin-attached bioadhesive patch enabling ultrasound deep brain stimulation and real-time electrophysiological monitoring for REM sleep enhancement.Nature communications · 2026Trial
- Acupuncture modulates emotional network resting-state functional connectivity in patients with insomnia disorder: a randomized controlled trial and fMRI study.BMC complementary medicine and therapies · 2024Trial
- Review
- Altered Individualized Structural Covariance Networks Underlie Depressive and Anxiety Symptoms in Chronic Insomnia Disorder: A Dynamic Time Warping Graph Theory Study.Brain and behavior · 2026Article
- Role of the Amygdala in the Complex Relationship Between Sleep and Anxiety.International journal of molecular sciences · 2026Review
- Network analysis of depression, anxiety, and NSSI symptoms in adolescents: a clinical sample study.BMC psychiatry · 2026Article
- Circadian rest/activity rhythms and change in MRI-derived brain volumes: Differences by age in a cognitively healthy sample.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Brain functional changes in chronic partial sleep-deprivation population by electroacupuncture at shenmen(HT7) and neiguan (PC6) acupoints: A BOLD-fMRI study.Integrative medicine research · 2026Article
- The Sleep Symptoms Are Directly Associated With Suicide Risk in Adolescents and Youth Patients With Depression.Depression and anxiety · 2026Article
- Adolescent Insomnia Disorder - Problematic Internet Use Nexus: A Convergent Developmental Trajectory - Bridging Neuroimaging Biomarkers, Molecular Susceptibility, and Environmental-Neurocognitive Cascades.Psychology research and behavior management · 2026Review
- Article
- The Tripartite Balance of Obesity, Sleep, and Brain: Current Knowledge and the Way Forward.Indian journal of pediatrics · 2025Article
- Sleep Behaviors and the Shape of Subcortical Brain Structures in Children with Overweight/Obesity: A Cross-Sectional Study.Indian journal of pediatrics · 2025Article
- Abnormal sensory processing cortex in insomnia disorder: a degree centrality study.Brain imaging and behavior · 2025Observational
- Exploring the Correlation Between Sleep Chronotype and the Volumes of Subcortical Structures and Hippocampal Subfields in Young Healthy Population.Brain sciences · 2025Article
- The basolateral amygdala-anterior cingulate cortex circuit contributes to postherpetic neuralgia-anxiety comorbidity.Theranostics · 2025Article
- Disentangling the effects of racism-related stress on opioid use disorder and chronic pain outcomes.The American journal of drug and alcohol abuse · 2024Article
- Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Affective disorders, such as anxiety and depression, are common comorbidities associated with chronic insomnia disorder (CID). However, the underlying neural mechanisms of these comorbidities are still not clear. The present study is aimed at investigating structural changes in the amygdala of CID patients using surface-based shape analysis. A total of 65 medication-naive patients with CID and 55 healthy controls (HCs) matched for age, sex, and years of education were enrolled in this study and were subjected to structural magnetic resonance imaging (MRI). The Oxford Centre for Functional MRI of the Brain (FMRIB) created an Integrated Registration and Segmentation Tool (FIRST) that was employed in this study to assess the volumetric and surface alterations in patients with CID. Shape correlations between the amygdala and clinical features were also analyzed. Atrophic changes in the amygdala were observed at the local level, not for the entire amygdala volume. The left atrophic changes in the amygdala were in the superficial and basolateral nuclei while right atrophic changes were in the basolateral nuclei in CID patients. Insomnia severity was associated with the centromedial right amygdala while anxiety was linked with the basolateral nuclei. These findings indicate localized amygdala atrophy in CID. Separate amygdala regions are associated with insomnia and anxiety in CID. This evidence helps elucidate the neural mechanisms underlying the bidirectional relationship between insomnia and anxiety.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.