Evidence map›Paper›PMID 31885499›Full record

ArticleMediators of inflammation2019

Imbalance of Circulatory T Follicular Helper and T Follicular Regulatory Cells in Patients with ANCA-Associated Vasculitis.

Ying Xu, Hongmei Xu, Yu Zhen, Xueting Sang, Hao Wu, Cong Hu, Zhanchuan Ma, Miaomiao Yu, Huanfa Yi

Open access · goldAbstract read
In one paragraph

Article in Mediators of inflammation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Article
  6. New Biomarkers for Systemic Necrotizing Vasculitides.Journal of clinical medicine · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ying XuCentral Laboratory of the Eastern Division, The First Hospital of Jilin University, Changchun, Jilin 130021, China.ORCID https://orcid.org/0000-0002-1122-8874
Hongmei XuDepartment of Obstetrics, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Yu ZhenDepartment of Dermatology, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Xueting SangUrology Center, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Hao WuUrology Center, The First Hospital of Jilin University, Changchun, Jilin 130021, China.ORCID https://orcid.org/0000-0001-5738-4015
Cong HuCentral Laboratory of the Eastern Division, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Zhanchuan MaCentral Laboratory of the Eastern Division, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Miaomiao YuCentral Laboratory of the Eastern Division, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Huanfa YiCentral Laboratory of the Eastern Division, The First Hospital of Jilin University, Changchun, Jilin 130021, China.ORCID https://orcid.org/0000-0003-3785-3691
Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antineutrophil cytoplasmic antibody- (ANCA-) associated vasculitis (AAV) is characterized by small-vessel inflammation in association with autoantibodies. Balance between T follicular helper (Tfh) cells and T follicular regulatory (Tfr) cells is critical for humoral immune responses. Accumulating evidence supports that Tfh and Tfr are involved in autoimmune diseases; however, their roles in AAV are unclear. In this study, we tested the changes of circulatory Tfh and Tfr in patients with AAV. Twenty patients with AAV and twenty healthy controls were enrolled. Sixteen AAV patients had kidney involvement. We found that the AAV patients had increased circulating Tfh cells (CD4

Indexed as

Acute Kidney InjuryAgedAnti-Neutrophil Cytoplasmic Antibody-Associated VasculitisEnzyme-Linked Immunosorbent AssayFemaleFlow CytometryHumansInterleukin-21InterleukinsMaleMiddle AgedT-Lymphocytes, Helper-InducerT-Lymphocytes, RegulatoryInterleukin-21Interleukins

Identifiers

PMID31885499
PMCPMC6914973
OpenAlexW2991486962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.