Evidence map›Paper›PMID 31885498›Full record

ArticleMediators of inflammation2019

Alpha-Lipoic Acid Protects Cardiomyocytes against Heat Stroke-Induced Apoptosis and Inflammatory Responses Associated with the Induction of Hsp70 and Activation of Autophagy.

Hsin-Hsueh Shen, Yu-Shiuan Tseng, Ni-Chun Kuo, Ching-Wen Kung, Sherif Amin, Kwok-Keung Lam, Yen-Mei Lee

Open access · goldAbstract read
In one paragraph

Article in Mediators of inflammation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Trial
  2. Review
  3. Ferroptosis in heatstroke: Mechanisms and therapeutic perspectives (Review).International journal of molecular medicine · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Inflammation, coagulation, and cellular injury in heat-induced shock.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
    Review
  9. Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Hsin-Hsueh ShenDepartment and Institute of Pharmacology, National Defense Medical Center, Taipei, Taiwan.
Yu-Shiuan TsengSchool of Medicine, National Defense Medical Center, Taipei, Taiwan.
Ni-Chun KuoSchool of Medicine, National Defense Medical Center, Taipei, Taiwan.
Ching-Wen KungDepartment of Nursing, Tzu Chi University of Science and Technology, Hualien, Taiwan.
Sherif AminDepartment of Pharmacology, New York Medical College, New York, USA.
Kwok-Keung LamDepartment of Anesthesiology, Catholic Mercy Hospital, Hsinchu, Taiwan.
Yen-Mei LeeDepartment and Institute of Pharmacology, National Defense Medical Center, Taipei, Taiwan.ORCID https://orcid.org/0000-0002-5855-5346
National Defense Medical Center · TWNew York Medical College · USTaipei Medical University · TWTri-Service General Hospital · TWTzu Chi University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heat stroke (HS) is a life-threatening illness and defined as when body temperature elevates above 40°C accompanied by the systemic inflammatory response syndrome that results in multiple organ dysfunctions.

Indexed as

AnimalsApoptosisAutophagyHeat StrokeHSP70 Heat-Shock ProteinsInflammationMaleMyocytes, CardiacNF-kappa BRatsRats, WistarSuperoxidesThioctic AcidTumor Necrosis Factor-alphaHSP70 Heat-Shock ProteinsNF-kappa BSuperoxidesThioctic AcidTumor Necrosis Factor-alpha

Identifiers

PMID31885498
PMCPMC6914879
OpenAlexW2991797153

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.