SynthesisMediators of inflammation2019
Plant Extracts in the Bone Repair Process: A Systematic Review.
Synthesis in Mediators of inflammation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Network Pharmacology and Molecular Docking Combined with In Vivo Validation to Elucidate the Molecular Mechanisms ofInternational journal of molecular sciences · 2026Article
- 7F2 Preosteoblast Cell Line Relative Viability Percentage after the Administration of 1% Roselle Flower Extract Nanoemulsion (Hibiscus sabdariffa Linn.).European journal of dentistry · 2026Article
- Effects of gold nanoparticles and apricot seeds on bone healing in New Zealand rabbits.Journal of Taibah University Medical Sciences · 2026Article
- Investigating the Osteoregenerative Properties ofJournal of functional biomaterials · 2025Article
- Advancements in Antimicrobial Surface Coatings Using Metal/Metaloxide Nanoparticles, Antibiotics, and Phytochemicals.Nanomaterials (Basel, Switzerland) · 2025Review
- An Anti-Oxidative Bioink for Cartilage Tissue Engineering Applications.Journal of functional biomaterials · 2024Article
- Enhancing Osteoblastic Cell Cultures with Gelatin Methacryloyl, Bovine Lactoferrin, and Bioactive Mesoporous Glass Scaffolds Loaded with Distinct Parsley Extracts.Biomolecules · 2023Article
- Graphene Oxide Nanostructures as Nanoplatforms for Delivering Natural Therapeutic Agents: Applications in Cancer Treatment, Bacterial Infections, and Bone Regeneration Medicine.Nanomaterials (Basel, Switzerland) · 2023Review
- Potential use of barks of woody vascular plants in bone mending: A review.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Review
- Evaluation of How Methacrylate Gelatin Hydrogel Loaded withJournal of functional biomaterials · 2023Article
- Effects of Combinations of Toxin Binders with or without Natural Components on Broiler Breeders Exposed to Ochratoxin A.Animals : an open access journal from MDPI · 2023Article
- Physicochemical Characterization of Novel Biomaterial Consisting of Biphasic Calcium Phosphate, Chitosan, Casein and Ethanolic Leaves Extract of Ormocarpum Cochinchinense.Journal of pharmacy & bioallied sciences · 2023Article
- Restoration of the Knee Medial Collateral Ligament and Complete Soft-tissue Coverage After Medial Open-Wedge High Tibial Osteotomy.Arthroscopy techniques · 2022Article
- Estrogen Receptor 1 (ESR1) and the Wnt/β-Catenin Pathway Mediate the Effect of the Coumarin Derivative Umbelliferon on Bone Mineralization.Nutrients · 2022Article
- Histological Evaluation of the Effect of Local Application ofInternational journal of biomaterials · 2022Article
- Pro-Osteogenic Properties ofNutrients · 2021Article
- Essential Oils for Bone Repair and Regeneration-Mechanisms and Applications.Materials (Basel, Switzerland) · 2021Review
- Acemannan-induced tooth socket healing: A 12-month randomized controlled trial.Journal of dental sciences · 2021Article
- Safety and Effectiveness of Copaiba Oleoresin (International journal of molecular sciences · 2020Article
- The effect of Aloe vera extract application on marginal bone preservation and socket reconstruction after tooth extraction - an animal study.Journal of oral biology and craniofacial researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone lesions are an important public health problem, with high socioeconomic costs. Bone tissue repair is coordinated by an inflammatory dynamic process mediated by osteoprogenitor cells of the periosteum and endosteum, responsible for the formation of a new bone matrix. Studies using antioxidant products from plants for bone lesion treatment have been growing worldwide. We developed a systematic review to compile the results of works with animal models investigating the anti-inflammatory activity of plant extracts in the treatment of bone lesions and analyze the methodological quality of the studies on this subject. Studies were selected in the PubMed/MEDLINE, Scopus, and Web of Science databases according to the PRISMA statement. The research filters were constructed using three parameters: animal model, bone repair, and plant extracts. 31 full-text articles were recovered from 10 countries. Phytochemical prospecting was reported in 15 studies (48.39%). The most common secondary metabolites were flavonoids, cited in 32.26% studies (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.