Evidence map›Paper›PMID 31885476›Full record

ArticleSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society2019

Green synthesis and biological evaluation of novel 5-fluorouracil derivatives as potent anticancer agents.

Farhat Jubeen, Aisha Liaqat, Misbah Sultan, Sania Zafar Iqbal, Imran Sajid, Farooq Sher

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Farhat JubeenDepartment of Chemistry, Government College Women University, Faisalabad 38000, Pakistan.
Aisha LiaqatDepartment of Chemistry, Government College Women University, Faisalabad 38000, Pakistan.
Misbah SultanDepartment of Chemistry, University of the Punjab, Lahore 54590, Pakistan.
Sania Zafar IqbalDepartment of Chemistry, Government College Women University, Faisalabad 38000, Pakistan.
Imran SajidDepartment of Chemistry, University of the Punjab, Lahore 54590, Pakistan.
Farooq SherDepartment of Chemical and Environmental Engineering, University of Nottingham, University Park, Nottingham NG7 2RD, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study reports the formation of 5-FU co-crystals with four different pharmacologically safe co-formers; Urea, Thiourea, Acetanilide and Aspirin using methanol as a solvent. Two fabrication schemes were followed i.e., solid-state grinding protocol, in which API and co-formers were mixed through vigorous grinding while in the other method separate solutions of both the components were made and mixed together. The adopted approaches offer easy fabrication protocols, no temperature maintenance requirements, no need of expensive solvents, hardly available apparatus, isolation and purification of the desired products. In addition, there is no byproducts formation, In fact, a phenomenon embracing the requirements of green synthesis. Through FTIR analysis; for API the N-H absorption frequency was recorded at 3409.02 cm

Indexed as

5-FluorouracilCo-crystalsGreen synthesisGrinding and solution methodSupramolecular interactions

Identifiers

PMID31885476
PMCPMC6921177

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.