Evidence map›Paper›PMID 31885466›Full record

ArticleSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society2019

Design, synthesis, and evaluation of novel 2-substituted 1,4-benzenediol library as antimicrobial agents against clinically relevant pathogens.

Daiane Flores Dalla Lana, Bruna Gerardon Batista, Gabriella da Rosa Machado, Mário Lettieri Teixeira, Luís Flávio Souza de Oliveira, Michel Mansur Machado, Saulo Fernandes de Andrade, William Lopes, Marilene Henning Vainstein, Alejandro Peixoto de Abreu Lima and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Isoflavaspidic Acid PB Extracted fromBioMed research international · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Daiane Flores Dalla LanaLaboratory of Applied Mycology, Department of Analysis, Faculty of Pharmacy, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Bruna Gerardon BatistaLaboratory of Applied Mycology, Department of Analysis, Faculty of Pharmacy, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Gabriella da Rosa MachadoLaboratory of Applied Mycology, Department of Analysis, Faculty of Pharmacy, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Mário Lettieri TeixeiraLaboratory of Biochemistry and Toxicology, Instituto Federal de Santa Catarina, Concordia, SC, Brazil.
Luís Flávio Souza de OliveiraCenter for Studies in Biochemistry, Immunology and Toxicology, Universidade Federal do Pampa, Uruguaiana, RS, Brazil.
Michel Mansur MachadoCenter for Studies in Biochemistry, Immunology and Toxicology, Universidade Federal do Pampa, Uruguaiana, RS, Brazil.
Saulo Fernandes de AndradeDepartment of Raw Materials Production, Faculty of Pharmacy, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
William LopesDepartment of Molecular Biology and Biotechnology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Marilene Henning VainsteinDepartment of Molecular Biology and Biotechnology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Alejandro Peixoto de Abreu LimaLaboratorio de Síntesis Orgánica, Departamento de Química Orgánica, Facultad de Química, CP11800, Universidad de la República, Montevideo, Uruguay.
Enrique PandolfiLaboratorio de Síntesis Orgánica, Departamento de Química Orgánica, Facultad de Química, CP11800, Universidad de la República, Montevideo, Uruguay.
Edilma Elayne SilvaDepartment of Organic Chemistry, Institute of Chemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Alexandre Meneghello FuentefriaLaboratory of Applied Mycology, Department of Analysis, Faculty of Pharmacy, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Gustavo Pozza SilveiraDepartment of Organic Chemistry, Institute of Chemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Universidade Federal do Rio Grande do Sul · BRUniversidad de la República · UYUniversidade Federal do Pampa · BRInstituto Federal de Educação, Ciência e Tecnologia de Santa Catarina · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Development of new antimicrobial agents, capable of combating resistant and multidrug-resistant fungal and bacterial clinical strains, is necessary. This study presents the synthesis and antimicrobial screening of 42 2-substituted-1,4-benzenediols, being 10 novel compounds. In total, 23 compounds showed activity against fungi and/or bacteria. Benzenediol compounds

Indexed as

1,4-benzenediol derivativesAntimicrobial activityESKAPE pathogensFungiMechanism of actionToxicity

Identifiers

PMID31885466
PMCPMC6921195
OpenAlexW2976956188

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.