Evidence map›Paper›PMID 31885251›Full record

ArticleBiochemistry2020

Structural Energy Landscapes and Plasticity of the Microstates of Apo

Rati Chkheidze, Wilfredo Evangelista, Mark A White, Y Whitney Yin, J Ching Lee

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Rati Chkheidze
Wilfredo EvangelistaCentro de Espectroscopia de Resonancia Magnética Nuclear (CERMN), Departamento de Ciencias-Química , Pontificia Universidad Católica del Perú , Lima 32 , Peru.
Mark A WhiteORCID 0000-0003-1057-4203
Y Whitney Yin
J Ching LeeORCID 0000-0003-0831-9545
The University of Texas Medical Branch at Galveston · USPontificia Universidad Católica del Perú · PE

Funding

Structural Basis for Antiviral Drug Mitochondrial ToxicityR01AI134611 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI YIN, YUHUI · 2018 to 2022
$2.0M
Role of Protein Dynamics in Modulating the Thermodynamic Linkages in AllosteryR01GM077551 · NIGMS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LEE, JAMES C · 2006 to 2009
$1.4M
Dissecting Dual Function of Pol gamma in mtDNA Replication and Oxidative Damage RepairR01GM110591 · NIGMS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI YIN, YUHUI · 2014 to 2018
$1.3M
NIAID NIH HHS R01 AI134611NIGMS NIH HHS R01 GM077551NIGMS NIH HHS R01 GM110591
6 · The paper itself

Abstract

The theory for allostery has evolved to a modern energy landscape ensemble theory, the major feature of which is the existence of multiple microstates in equilibrium. The properties of microstates are not well defined due to their transient nature. Characterization of apo protein microstates is important because the specific complex of the ligand-bound microstate defines the biological function. The information needed to link biological function and structure is a quantitative correlation of the energy landscapes between the apo and holo protein states. We employed the

Indexed as

Allosteric RegulationComputational BiologyCyclic AMPCyclic AMP Receptor ProteinEscherichia coliEscherichia coli ProteinsModels, MolecularProtein ConformationThermodynamicsCyclic AMPCyclic AMP Receptor ProteinEscherichia coli Proteins

Identifiers

PMID31885251
PMCPMC7187730
OpenAlexW2996827697

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.