Evidence map›Paper›PMID 31885211›Full record

ArticleActa ophthalmologica2020

Body size at birth and age-related macular degeneration in old age.

Markus J Haapanen, Mikaela B von Bonsdorff, Diana Fisher, Fridbert Jonasson, Gudny Eiriksdottir, Vilmundur Gudnason, Mary Frances Cotch

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta ophthalmologica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 79% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Markus J HaapanenDepartment of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID https://orcid.org/0000-0002-8632-7906
Mikaela B von BonsdorffFolkhälsan Research Center, Helsinki, Finland.
Diana FisherDivision of Epidemiology and Clinical Applications, Intramural Research Program, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA.
Fridbert JonassonFaculty of Medicine, University of Iceland, Reykjavik, Iceland.
Gudny EiriksdottirFaculty of Medicine, University of Iceland, Reykjavik, Iceland.
Vilmundur GudnasonFaculty of Medicine, University of Iceland, Reykjavik, Iceland.
Mary Frances CotchDivision of Epidemiology and Clinical Applications, Intramural Research Program, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA.
University of Iceland · ISNational Institutes of Health · USFolkhälsans Forskningscentrum · FIUniversity of Helsinki · FI

Funding

Age, Gene/environment Susceptibility Study In Iceland - Ocular ComponentZIAEY000401 · NEI · NATIONAL EYE INSTITUTE · PI COTCH, MARY FRANCES · 2009 to 2020
$3.3M
Gene/environment Susceptibility Iceland-Ocular ComponentZ01EY000401 · NEI · NATIONAL EYE INSTITUTE · PI COTCH, MARY FRANCES · 2002 to 2008
$258k
Intramural NIH HHS Z01 EY000401Intramural NIH HHS ZIA EY000401NEI NIH HHS N01-AG-1-2100NEI NIH HHS ZIAEY00401
6 · The paper itself

Abstract

purposeTo study associations between body size at birth and age-related macular degeneration (AMD) in old age.

methodsThe study sample consists of 1497 community-dwelling individuals (56.1% women) aged 67-89 years with birth data and retinal data collected twice in old age 5 years apart. Birth data (weight, length, birth order) were extracted from original birth records. Digital retinal photographs were graded to determine AMD status. Data on covariates were collected at the baseline physical examination in old age. Multivariable regression analyses were used to study the association between birth data and AMD adjusting for known confounding factors, including birth year cohort effects.

resultsThe prevalence and 5-year incidence of any AMD were 33.1% and 17.0%, respectively. Men and women born in 1930-1936 were significantly leaner and slightly longer at birth compared to those in earlier birth cohorts. There were no consistent associations between weight, length or ponderal index (PI) at birth and AMD in old age even when stratified by birth cohort. Age-related macular degeneration (AMD) prevalence (39.8%) and 5-year incidence (28.6%) were highest in individuals who were in the highest quartile of PI at birth and who were obese in old age.

conclusionBody size at birth was not consistently associated with AMD in old age, suggesting that intrauterine growth might have little direct importance in the development of AMD in old age. It is possible that some yet unknown factors related to larger size at birth and obesity in old age may explain differences in the prevalence and incidence of AMD in the ageing population.

Indexed as

age-related macular degenerationbody size at birth

Identifiers

PMID31885211
PMCPMC7321907
OpenAlexW2997553044

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.