ArticlePediatric diabetes2020
Mechanisms linking childhood weight status to metabolic risk in adolescence.
Article in Pediatric diabetes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Screen time, sleep duration, leisure physical activity, obesity, and cardiometabolic risk in children and adolescents: a cross-lagged 2-year study.BMC cardiovascular disorders · 2024Observational
- The stability of cardiometabolic risk factors clustering in children and adolescents: a 2-year longitudinal study.Journal of diabetes and metabolic disorders · 2023Article
- Efficacy of Liraglutide in Obesity in Children and Adolescents: Systematic Review and Meta-Analysis of Randomized Controlled Trials.Children (Basel, Switzerland) · 2023Review
- What is the role of cardiorespiratory fitness and sedentary behavior in relationship between the genetic predisposition to obesity and cardiometabolic risk score?BMC cardiovascular disorders · 2022Article
- Sleep duration, physical activity, and caloric intake are related to weight status in Mexican American children: a longitudinal analysis.The international journal of behavioral nutrition and physical activity · 2021Article
- Childhood Obesity in Serbia on the Rise.Children (Basel, Switzerland) · 2021Article
- Liraglutide for management of adolescent obesity.Nature reviews. Endocrinology · 2020Article
- Overuse of Non-caloric Sweeteners in Foods and Beverages in Chile: A Threat to Consumers' Free Choice?Frontiers in nutrition · 2020Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundObesity is a risk factor for insulin resistance (IR) and metabolic disease.
objectiveTo examine potential metabolic pathways linking childhood weight status to adolescent IR and metabolic risk.
methodsParticipants were 600 low- to middle-income Chilean adolescents from a cohort studied since infancy as part of an iron deficiency anemia preventive trial and follow-up study. We examined body mass index z-score at 10 y (BMIz-10y) and blood pressure, total fat, and fasting glucose, adiponectin to leptin ratio (A:L), ghrelin, and HOMA-IR at 16 y. A total count for metabolic risk factors (MRF) was calculated using the International Diabetes Federation criteria. We used path analysis to estimate pathways and model indirect effects from BMIz-10y, controlling for child age and sex and maternal body mass index (BMI).
resultsParticipants were 54% male; mean BMIz-10y of 0.53 (SD = 1.02); mean MRF of 1.3 (SD = 0.9); mean HOMA-IR of 1.8 (SD = 1.3). Path analysis showed that BMIz-10y directly and indirectly related to increased MRF via A:L and HOMA-IR. Ghrelin was not in the metabolic pathway from BMIz-10y to MRF but was related to MRF via HOMA-IR.
conclusionThese results elucidate metabolic pathways involving child weight status, IR and metabolic risk in adolescents. Childhood BMI was an indirect risk factor for adolescent cardiometabolic risk via several pathways that involved BMI, appetite hormones, markers of inflammation, and insulin resistance during adolescence. Findings illustrate the adverse effect that childhood obesity has on adolescent health outcomes, which sets precedence for health outcomes over the life course.
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