ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2020
Cilia oscillations.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Embodied behavioural complexity in a ciliated microorganism.Nature communications · 2026Article
- Article
- Form and function in biological filaments: a physicist's review.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025Review
- The reaction-diffusion basis of animated patterns in eukaryotic flagella.Nature communications · 2023Article
- Spontaneous phase coordination and fluid pumping in model ciliary carpets.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Driving a Microswimmer with Wall-Induced Flow.Micromachines · 2021Article
- Intracellular coupling modulates biflagellar synchrony.Journal of the Royal Society, Interface · 2021Article
- Synchrony and symmetry-breaking in active flagellar coordination.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- On the unity and diversity of cilia.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cilia, or eukaryotic flagella, are microscopic active filaments expressed on the surface of many eukaryotic cells, from single-celled protozoa to mammalian epithelial surfaces. Cilia are characterized by a highly conserved and intricate internal structure in which molecular motors exert forces on microtubule doublets causing cilia oscillations. The spatial and temporal regulations of this molecular machinery are not well understood. Several theories suggest that geometric feedback control from cilium deformations to molecular activity is needed. Here, we implement a recent sliding control model, where the unbinding of molecular motors is dictated by the sliding motion between microtubule doublets. We investigate the waveforms exhibited by the model cilium, as well as the associated molecular motor dynamics, for hinged and clamped boundary conditions. Hinged filaments exhibit base-to-tip oscillations while clamped filaments exhibit both base-to-tip and tip-to-base oscillations. We report the change in oscillation frequencies and amplitudes as a function of motor activity and sperm number, and we discuss the validity of these results in the context of experimental observations of cilia behaviour. This article is part of the Theo Murphy meeting issue 'Unity and diversity of cilia in locomotion and transport'.
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