Evidence map›Paper›PMID 31884913›Full record

ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2020

Testing the role of intraflagellar transport in flagellar length control using length-altering mutants of

Kimberly Wemmer, William Ludington, Wallace F Marshall

Abstract read
In one paragraph

Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Frontiers in cell and developmental biology · 2024
    Review
  7. Article
  8. Review
  9. Article
  10. The short flagella 1 (SHF1) gene inMolecular biology of the cell · 2022
    Article
  11. Article
  12. Intraflagellar Transport Proteins as Regulators of Primary Cilia Length.Frontiers in cell and developmental biology · 2021
    Review
  13. Article
  14. Scaling of Subcellular Structures.Annual review of cell and developmental biology · 2020
    Review
  15. On the unity and diversity of cilia.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kimberly WemmerDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA.
William LudingtonDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA.
Wallace F MarshallDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA.

Funding

Origins of Cell GeometryR35GM130327 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Wallace Marshall · 2019 to 2026
$5.3M
Modeling and Analysis of the Flagellar Length Control SystemR01GM097017 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARSHALL, WALLACE · 2011 to 2018
$2.1M
NIGMS NIH HHS R01 GM097017NIGMS NIH HHS R35 GM130327
6 · The paper itself

Abstract

Cilia and flagella are ideal model organelles in which to study the general question of organelle size control. Flagellar microtubules are steady-state structures whose size is set by the balance of assembly and disassembly. Assembly requires intraflagellar transport (IFT), and measurements of IFT have shown that the rate of entry of IFT particles into the flagellum is a decreasing function of length. It has been proposed that this length dependence of IFT may be the basis for flagellar length control. Here, we test this idea by showing that three different long-flagella mutations in

Indexed as

ChlamydomonasFlagellaMicrotubulesModels, TheoreticalMutationProtein TransportTubulinTubulinChlamydomonasintraflagellar transportorganelle size control

Identifiers

PMID31884913
PMCPMC7017341

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.