Evidence map›Paper›PMID 31884861›Full record

ArticleThe Journal of international medical research2020

miR-147a suppresses the metastasis of non-small-cell lung cancer by targeting

Yan Lu, Xiao Rong Luan

RetractedAbstract readRetracted Publication
In one paragraph

Article in The Journal of international medical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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  17. Review
  18. CircPSMC3 Suppresses Migration and Invasion of Non-Small Cell Lung Cancer Cells via miR-182-5p/NME2 Axis.Medical science monitor : international medical journal of experimental and clinical research · 2020
    Article
4 · The record

Corrections and comments

  • Retraction · 2025-10-08Concerns/Issues about Authorship/Affiliation · Concerns/Issues about Referencing/Attributions · Concerns/Issues about Third Party Involvement · Investigation by Journal/Publisher · Investigation by Third Party · · See also: https://pubpeer.com/publications/5ED790D1ED57CCAB7A6A93885801E5#0
  • Retracted
5 · Who and what money

Authors and funding

2 authors.

Yan LuNursing Department, Qilu Hospital of Shandong University, Jinan, Shandong, China.ORCID https://orcid.org/0000-0001-9869-5389
Xiao Rong LuanNursing Department, Qilu Hospital of Shandong University, Jinan, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveMicroRNA (miR)-147a acts as an inhibitory miRNA in many cancers. However, its potential roles in non-small-cell lung cancer (NSCLC) remain unclear.

methodsLevels of miR-147a and C-C motif chemokine ligand 5 (CCL5) were measured using a quantitative real-time PCR assay. Cell growth, migration, and invasion of NSCLC cells were assessed by colony formation, wound healing, and Transwell invasion assays, respectively. The role of miR-147a in the growth and metastatic ability of NSCLC

resultsmiR-147a was downregulated in NSCLC cell lines as well as in tissues. Gain-of-function and loss-of-function analyses demonstrated that upregulation of miR-147a decreased the aggressiveness of NSCLC cells

conclusionsOverall, expression of miR-147a was downregulated in NSCLC. Importantly, upregulation of miR-147a suppressed the growth and metastasis of NSCLC cells

Indexed as

Carcinoma, Non-Small-Cell LungChemokine CCL5Lung NeoplasmsMicroRNAsAnimalsCell Line, TumorCell MovementCell ProliferationHumansMiceNeoplasm TransplantationCCL5 protein, humanChemokine CCL5MicroRNAsMIRN147 microRNA, humanCCL5C-C motif chemokine ligand 5invasionmetastasismigrationmiR-147anon-small-cell lung cancerNSCLC

Identifiers

PMID31884861
PMCPMC7607764

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.