Evidence map›Paper›PMID 31884678›Full record

ArticleCell biology and toxicology2020

Evidence for the critical role of the PI3K signaling pathway in particulate matter-induced dysregulation of the inflammatory mediators COX-2/PGE

Chenjian Song, Lingjing Liu, Junjie Chen, Yiran Hu, Jingli Li, Beibei Wang, Saverio Bellusci, Chengshui Chen, Nian Dong

Open access · hybridAbstract read
In one paragraph

Article in Cell biology and toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Amelioration of Ambient Particulate Matter (PMFrontiers in physiology · 2021
    Article
  12. Skin barrier dysfunction and filaggrin.Archives of pharmacal research · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Chenjian SongDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Lingjing LiuDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Junjie ChenDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Yiran HuDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Jingli LiDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Beibei WangDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Saverio BellusciDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Chengshui ChenDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. wzchencs@163.com.
Nian DongDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. wzmudongnian@foxmail.com.
First Affiliated Hospital of Wenzhou Medical University · CNWenzhou Medical University · CNCardio-Pulmonary Institute · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Particulate matter (PM) is an environmental pollutant closely associated with human airway inflammation. However, the molecular mechanisms of PM-related airway inflammation remains to be fully elucidated. It is known that COX-2/PGE

Indexed as

AnimalsCell LineCyclooxygenase 2Epithelial CellsEpitheliumFilaggrin ProteinsHumansIntermediate Filament ProteinsMice, Inbred C57BLParticulate MatterPhosphatidylinositol 3-KinasesCyclooxygenase 2Filaggrin ProteinsFLG protein, humanIntermediate Filament ProteinsParticulate MatterPhosphatidylinositol 3-KinasesBronchial epithelial damageCOX-2/PGE2FilaggrinPI3K/AKTPM

Identifiers

PMID31884678
PMCPMC7363729
OpenAlexW2997741444

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.