Evidence map›Paper›PMID 31884667›Full record

ReviewAdvances in experimental medicine and biology2019

RPE65 Palmitoylation: A Tale of Lipid Posttranslational Modification.

Sheetal Uppal, Eugenia Poliakov, Susan Gentleman, T Michael Redmond

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. The Amphipathic Helix in Visual Cycle Proteins: A Review.Advances in experimental medicine and biology · 2023
    Review
  3. Retinal pigment epithelium 65 kDa protein (RPE65): An update.Progress in retinal and eye research · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sheetal UppalLaboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Eugenia PoliakovLaboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Susan GentlemanLaboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
T Michael RedmondLaboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA. redmondd@helix.nih.gov.
National Institutes of Health · USNational Eye Institute · US

Funding

MOLECULAR BIOLOGY OF OUTER RETINA-SPECIFIC PROTEINSZ01EY000260 · NEI · NATIONAL EYE INSTITUTE · PI REDMOND, THOMAS M · 1990 to 2008
$3.7M
Intramural NIH HHS Z01 EY000260
6 · The paper itself

Abstract

RPE65, the retinal pigment epithelium (RPE) smooth endoplasmic reticulum (sER) membrane-associated retinoid isomerase, plays an indispensable role in sustaining visual function in vertebrates. An important aspect which has attracted considerable attention is the posttranslational modification by S-palmitoylation of RPE65. Some studies show that RPE65 is a palmitoylated protein, but others deny that conclusion. While it is considered to be mainly responsible for RPE65's membrane association, we still lack conclusive evidence about RPE65 palmitoylation. In this review, we provide an overview of the history and current understanding of RPE65 palmitoylation.

Indexed as

LipoylationProtein Processing, Post-TranslationalAnimalscis-trans-IsomerasesEndoplasmic ReticulumEye ProteinsHumansLipidsRetinal Pigment EpitheliumRetinoid Isomerohydrolasecis-trans-IsomerasesEye ProteinsLipidsRetinoid IsomerohydrolaseMembrane associationPosttranslational modificationRetinoid isomeraseRPE65Smooth endoplasmic reticulumS-palmitoylation

Identifiers

PMID31884667
PMCPMC9351226
OpenAlexW2997479509

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.