Evidence map›Paper›PMID 31884649›Full record

ArticleAdvances in experimental medicine and biology2019

Analysis of Damage and Wound Healing in the Retinal Pigmented Epithelium.

K J Donaldson, W F Wu, H Skelton, S Markand, S Ferdous, J Sellers, M A Chrenek, I Gefke, S M Kim, J Rha and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in experimental medicine and biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 76% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

K J DonaldsonDepartment of Ophthalmology, Emory University, Atlanta, GA, USA.
W F WuDepartment of Ophthalmology, Emory University, Atlanta, GA, USA.
H SkeltonMorehouse School of Medicine, Atlanta, GA, USA.
S MarkandDepartment of Ophthalmology, Emory University, Atlanta, GA, USA.
S FerdousDepartment of Ophthalmology, Emory University, Atlanta, GA, USA.
J SellersDepartment of Ophthalmology, Emory University, Atlanta, GA, USA.
M A ChrenekDepartment of Ophthalmology, Emory University, Atlanta, GA, USA.
I GefkeDepartment of Ophthalmology, Emory University, Atlanta, GA, USA.
S M KimDepartment of Ophthalmology, Emory University, Atlanta, GA, USA.
J RhaDepartment of Ophthalmology, Emory University, Atlanta, GA, USA.
K L LiaoDepartment of Ophthalmology, Emory University, Atlanta, GA, USA.
H E GrossniklausDepartment of Ophthalmology, Emory University, Atlanta, GA, USA.
Y JiangMath and Stats, Georgia State University, Atlanta, GA, USA.
J KongMath and Stats, Georgia State University, Atlanta, GA, USA.
J H BoatrightDepartment of Ophthalmology, Emory University, Atlanta, GA, USA.
John M NickersonDepartment of Ophthalmology, Emory University, Atlanta, GA, USA. litjn@emory.edu.
Emory University · USGeorgia State University · USMorehouse School of Medicine · US

Funding

P30-Core Grant for Vision Research Core CP30EY006360 · NEI · EMORY UNIVERSITY · PI PARDUE, MACHELLE T. · 1986 to 2025
$15.3M
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008490 · NIGMS · EMORY UNIVERSITY · PI BOSS, JEREMY M. · 1993 to 2022
$8.0M
VIsion Science Training in AtlantaT32EY007092 · NEI · EMORY UNIVERSITY · PI Machelle T. Pardue · 1985 to 2026
$4.6M
Ocular Growth, Emmetropia, and Interphotoreceptor Retinoid-Binding Protein (IRBP)R01EY021592 · NEI · EMORY UNIVERSITY · PI BOATRIGHT, JEFFREY H, IUVONE, P MICHAEL · 2013 to 2021
$3.3M
The RPE and Recovery of the Blood Retina BarrierR01EY028450 · NEI · EMORY UNIVERSITY · PI BOATRIGHT, JEFFREY H, GROSSNIKLAUS, HANS E. · 2018 to 2022
$2.4M
Exercise-induced Retinal NeuroprotectionR01EY028859 · NEI · EMORY UNIVERSITY · PI BOATRIGHT, JEFFREY H, PARDUE, MACHELLE T. · 2018 to 2021
$2.0M
Deciphering the Usher I protein interactome using a genetic approachR01DC009246 · NIDCD · CASE WESTERN RESERVE UNIVERSITY · PI ZHENG, QING Y · 2009 to 2013
$1.6M
Retina Differential Gene Expression Modifiers that affect VisionF31EY028855 · NEI · EMORY UNIVERSITY · PI FERDOUS, SALMA · 2018 to 2020
$125k
NEI NIH HHS F31 EY028855NEI NIH HHS P30 EY006360NEI NIH HHS R01 EY021592NEI NIH HHS R01 EY028450NEI NIH HHS R01 EY028859NEI NIH HHS T32 EY007092NIDCD NIH HHS R01 DC009246NIGMS NIH HHS T32 GM008490RRD VA I01 RX002806RRD VA I21 RX001924
6 · The paper itself

Abstract

Previous studies of retinal pigment epithelium (RPE) morphology found cell-level and spatial patterning differences in many quantitative metrics in comparing normal and disease conditions. However, most of these studies examined eyes from deceased animals. Here we sought to compare noninvasively imaged RPE cells from live mice to histopathology. We describe changes to improve noninvasive imaging of RPE in the live mouse. In retinal diseases, there can be invasion by Iba1-positive cells, which can be detected by noninvasive imaging techniques. Here we can detect potential Iba1-positive cells at the level of the RPE noninvasively.

Indexed as

Wound HealingAnimalsMiceRetinal Pigment EpitheliumBest1Confetti mouse lineCreFlat-mountingHistopathologyInherited retinal diseasesNoninvasive imagingRetinal pigmented epithelium (RPE)Transgenic mice

Identifiers

PMID31884649
PMCPMC7362297
OpenAlexW2996840296

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.