Evidence map›Paper›PMID 31884423›Full record

ArticleAging2019

The loss of dopaminergic neurons in DEC1 deficient mice potentially involves the decrease of PI3K/Akt/GSK3β signaling.

Zhu Zhu, Wu Yichen, Zhang Ziheng, Ge Dinghao, Lu Ming, Liu Wei, Shan Enfang, Hu Gang, Hiroaki Honda, Yang Jian

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. IL-6 Enhances the Activation of PI3K-AKT/mTOR-GSK-3β by Upregulating GRPR in Hippocampal Neurons of Autistic Mice.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2024
    Article
  2. Review
  3. Frontiers in pharmacology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Zhu ZhuDepartment of Pharmacology, Nanjing Medical University, Nanjing, China.
Wu YichenDepartment of Pharmacology, Nanjing Medical University, Nanjing, China.
Zhang ZihengDepartment of Pharmacology, Nanjing Medical University, Nanjing, China.
Ge DinghaoDepartment of Pharmacology, Nanjing Medical University, Nanjing, China.
Lu MingDepartment of Pharmacology, Nanjing Medical University, Nanjing, China.
Liu WeiDepartment of Pharmacology, Nanjing Medical University, Nanjing, China.
Shan EnfangDepartment of Pharmacology, Nanjing Medical University, Nanjing, China.
Hu GangDepartment of Pharmacology, Nanjing Medical University, Nanjing, China.
Hiroaki HondaResearch Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Yang JianDepartment of Pharmacology, Nanjing Medical University, Nanjing, China.
Nanjing Medical University · CNHiroshima University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here we study the effects of differentiated embryonic chondrocyte gene 1(DEC1) deficiency on midbrain dopaminergic(DA) neurons in the substantia nigra pars compacta(SNpc) through behavioral, histological and molecular analysis. We have found that compared to the age-matched WT mice, DEC1 deficient mice show a decrease in locomotor activity and motor coordination, which shows the main features of Parkinson's disease(PD). But there is no significant difference in spatial learning and memory skills between WT and DEC1 KO mice. Compared to the age-matched WT mice, DEC1 deficient mice exhibit the loss of DA neurons in the SNpc and reduction of dopamine and its metabolites in the striatum. The activated caspase-3 and TH/TUNEL

Indexed as

AgingAnimalsBasic Helix-Loop-Helix ProteinsFemaleGlycogen Synthase Kinase 3 betaHomeodomain ProteinsMaleMiceMice, KnockoutNerve DegenerationPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktBasic Helix-Loop-Helix ProteinsBhlhe40 protein, mouseGlycogen Synthase Kinase 3 betaGsk3b protein, mouseHomeodomain ProteinsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktdifferentiated embryonic chondrocyte gene 1 (DEC1)dopaminergic (DA) neuronsParkinson's disease (PD)PI3K/Akt/GSK3β signaling

Identifiers

PMID31884423
PMCPMC6949058
OpenAlexW2998773327

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.