ArticleBrain stimulation
Continuous deep brain stimulation of the subthalamic nucleus may not modulate beta bursts in patients with Parkinson's disease.
Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Temporal Dynamics of Microlesion Effects in Subthalamic Local Field Potentials.Neurologia medico-chirurgica · 2026Article
- Subthalamic stimulation evokes hyperdirect high beta interruption and cortical high gamma entrainment in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Flexible graphene-based neurotechnology for high-precision deep brain mapping and neuromodulation in Parkinsonian rats.Nature communications · 2025Article
- The Neurostimulationist will see you now: prescribing direct electrical stimulation therapies for the human brain in epilepsy and beyond.Frontiers in human neuroscience · 2024Review
- Hybrid CNN-LSTM model with efficient hyperparameter tuning for prediction of Parkinson's disease.Scientific reports · 2023Article
- Average power and burst analysis revealed complementary information on drug-related changes of motor performance in Parkinson's disease.NPJ Parkinson's disease · 2023Article
- When do bursts matter in the primary motor cortex? Investigating changes in the intermittencies of beta rhythms associated with movement states.Progress in neurobiology · 2023Article
- Novel approaches for quantifying beta synchrony in Parkinson's disease.Experimental brain research · 2022Review
- Balance between competing spectral states in subthalamic nucleus is linked to motor impairment in Parkinson's disease.Brain : a journal of neurology · 2022Article
- Stimulating at the right time to recover network states in a model of the cortico-basal ganglia-thalamic circuit.PLoS computational biology · 2022Article
- Article
- Eight-hours conventional versus adaptive deep brain stimulation of the subthalamic nucleus in Parkinson's disease.NPJ Parkinson's disease · 2021Article
- Early decreases in cortical mid-gamma peaks coincide with the onset of motor deficits and precede exaggerated beta build-up in rat models for Parkinson's disease.Neurobiology of disease · 2021Article
- Average beta burst duration profiles provide a signature of dynamical changes between the ON and OFF medication states in Parkinson's disease.PLoS computational biology · 2021Article
- Longitudinal analysis of local field potentials recorded from directional deep brain stimulation lead implants in the subthalamic nucleus.Journal of neural engineering · 2021Article
- Levodopa-Induced Dyskinesia Is Mediated by Cortical Gamma Oscillations in Experimental Parkinsonism.Movement disorders : official journal of the Movement Disorder Society · 2021Article
- Parkinsonism Alters Beta Burst Dynamics across the Basal Ganglia-Motor Cortical Network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- A novel method for calculating beta band burst durations in Parkinson's disease using a physiological baseline.Journal of neuroscience methods · 2020Article
- [Design and verification of microelectrode twisting machine].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020Article
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4 authors.
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Abstract
backgroundNeural oscillations represent synchronous neuronal activation and are ubiquitous throughout the brain. Oscillatory activity often includes brief high-amplitude bursts in addition to background oscillations, and burst activity may predict performance on working memory, motor, and comprehension tasks.
objectiveWe evaluated beta burst activity as a possible biomarker for motor symptoms in Parkinson's disease (PD). The relationship between beta amplitude dynamics and motor symptoms is critical for adaptive DBS for treatment of PD.
methodsWe applied threshold-based and support vector machine (SVM) analyses of burst parameters to a defined on/off oscillator and to intraoperative recordings of local field potentials from the subthalamic nucleus of 16 awake patients with PD.
resultsFiltering and time-frequency analysis techniques critically influenced the accuracy of identifying burst activity. Threshold-based analysis lead to biased results in the presence of changes in long-term beta amplitude and accurate quantification of bursts with thresholds required unknowable a priori knowledge of the time in bursts. We therefore implemented an SVM analysis, and we did not observe changes in burst fraction, rate, or duration with the application of cDBS in the participant data, even though SVM analysis was able to correctly identify bursts of the defined on/off oscillator.
conclusionOur results suggest that cDBS of the STN may not change beta burst activity. Additionally, threshold-based analysis can bias the fraction of time spent in bursts. Improved analysis strategies for continuous and adaptive DBS may achieve improved symptom control and reduce side-effects.
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