ReviewFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association2020
The toxicity of the methylimidazolium ionic liquids, with a focus on M8OI and hepatic effects.
Review in Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 84 citations in OpenAlex.
- PFAS-like behavior of alkylimidazolium ionic liquids: chain-length-dependent toxicokinetics and PBTK-based risk implications.Archives of toxicology · 2026Article
- Neurobehavioural Effects of the Methylimidazolium Ionic Liquid M8OI in Rats.Journal of xenobiotics · 2026Article
- Beyond the Solvent: Engineering Ionic Liquids for Biomedical Applications-Advances, Challenges, and Future Directions.Molecules (Basel, Switzerland) · 2026Review
- Benchmark Dose Estimation from Transcriptomics Data for Methylimidazolium Ionic Liquid Hepatotoxicity: Implications for Health Risk Assessment of Green Solvents.Environment & health (Washington, D.C.) · 2025Article
- Ionic liquids and their potential use in development and improvement of drug delivery systems: evidence of their tendency to promote drug accumulation in the brain.Pharmaceutical development and technology · 2024Review
- 1-Butyl-3-methylimidazolium-Based Ionic Liquid in Biomass Fractionation-Green Solvent or Active Reagent Toward Lignin Compounds?International journal of molecular sciences · 2024Article
- Ionic Liquid 1-Octyl-3-Methylimidazolium (M8OI) Is Mono-Oxygenated by CYP3A4 and CYP3A5 in Adult Human Liver.Journal of xenobiotics · 2024Article
- Capacity of Aqueous Solutions of the Ionic Liquid 1-Ethyl-3-methylimidazolium Acetate to Partially Depolymerize Lignin at Ambient Temperature and Pressure.Journal of agricultural and food chemistry · 2024Article
- An insight into pharmaceutical challenges with ionic liquids: where do we stand in transdermal delivery?Frontiers in bioengineering and biotechnology · 2024Review
- Insight into the negative effect and lipid profile alterations in liver of mice exposed to methylimidazolium ionic liquids, a novel "green" solvent.Toxicology research · 2023Article
- The Nanostructure of Alkyl-Sulfonate Ionic Liquids: Two 1-Alkyl-3-methylimidazolium Alkyl-Sulfonate Homologous Series.Molecules (Basel, Switzerland) · 2023Article
- Potential for cardiac toxicity with methylimidazolium ionic liquids.Ecotoxicology and environmental safety · 2023Article
- Recent Advances in Deep Eutectic Solvents as Shale Swelling Inhibitors: A Comprehensive Review.ACS omega · 2022Review
- Neurotoxicity of Chronic Co-Exposure of Lead and Ionic Liquid in Common Carp: Synergistic or Antagonistic?International journal of molecular sciences · 2022Article
- Mimic Nature Using Chemotaxis of Ionic Liquid Microdroplets for Drug Delivery Purposes.Molecules (Basel, Switzerland) · 2022Review
- Electrode-Electrolyte Interactions in an Aqueous Aluminum-Carbon Rechargeable Battery System.Nanomaterials (Basel, Switzerland) · 2021Article
- The methylimidazolium ionic liquid M8OI is detectable in human sera and is subject to biliary excretion in perfused human liver.Toxicology · 2021Article
- Ionic Liquids-A Review of Their Toxicity to Living Organisms.International journal of molecular sciences · 2021Review
- Mechanisms of action of ionic liquids on living cells: the state of the art.Biophysical reviews · 2020Review
- Renal injury and hepatic effects from the methylimidazolium ionic liquid M8OI in mouse.Ecotoxicology and environmental safety · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ionic liquids are a diverse range of charged chemicals with low volatility and often liquids at ambient temperatures. This characteristic has in part lead to them being considered environmentally-friendly replacements for existing volatile solvents. However, methylimidazolium ionic liquids are slow to break down in the environment and a recent study at Newcastle detected 1 octyl 3 methylimidazolium (M8OI) - an 8 carbon variant methylimidazolium ionic liquid - in soils in close proximity to a landfill site. The current M8OI toxicity database in cultured mammalian cells, in experimental animal studies and in model indicators of environmental impact are reviewed. Selected analytical data from the Newcastle study suggest the soils in close proximity to the landfill site, an urban soil lacking overt contamination, had variable levels of M8OI. The potential for M8OI - or a structurally related ionic liquid - to trigger primary biliary cholangitis (PBC), an autoimmune liver disease thought to be triggered by an unknown agent(s) in the environment, is reviewed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.