ArticleSchizophrenia research2020
Characteristics of youth with reported family history of psychosis spectrum symptoms in the Philadelphia Neurodevelopmental Cohort.
Article in Schizophrenia research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Immune and oxidative stress biomarkers in pediatric psychosis and psychosis-risk: Meta-analyses and systematic review.Brain, behavior, and immunity · 2024Pooled it
- Time to Clinical Response in the Treatment of Early Onset Schizophrenia Spectrum Disorders Study.Journal of child and adolescent psychopharmacology · 2021Trial
- Mediating Role of Trauma Connecting Psychiatric Family History and Adolescent Mental Health.Biological psychiatry global open science · 2025Article
- Familial High-Risk for Psychosis and Bipolar Disorder Amongst Youth in an Academic Healthcare System: A Real-World Assessment of Clinical Characteristics and Implications for Clinical Care.Early intervention in psychiatry · 2025Article
- Association of Polygenic Risk Scores for Schizophrenia with Psychosis-Proneness Indicators in the General Population: A Narrative Review.Consortium psychiatricum · 2025Review
- Five-year follow-up of the iBerry Study: screening in early adolescence to identify those at risk of psychopathology in emerging adulthood.European child & adolescent psychiatry · 2024Article
- The effect of stressful life events on the risk for psychosis: differences between Mexican at clinical and familial high risk.Frontiers in psychiatry · 2023Article
- Issues in Estimating Interpretable Lower Order Factors in Second-Order Hierarchical Models: Commentary on Clark et al. (2021).Clinical psychological science : a journal of the Association for Psychological Science · 2022Article
- Clinical and Functional Differences Between Mexican Youth at Clinical High Risk for Psychosis and With Familial High Risk.Frontiers in psychology · 2022Article
- Psychotic-like Experiences and Polygenic Liability in the Adolescent Brain Cognitive Development Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- Natural language processing methods are sensitive to sub-clinical linguistic differences in schizophrenia spectrum disorders.NPJ schizophrenia · 2021Article
- Familial and socioeconomic contributions to premorbid functioning in psychosis: Impact on age at onset and treatment response.European psychiatry : the journal of the Association of European Psychiatrists · 2020Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
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Abstract
Little is known about the impact of family history of psychosis on youth from community samples. To fill this gap, we compared youth with a first-degree relative with psychosis spectrum symptoms (i.e. family history of psychosis spectrum symptoms, FHPS) to youth without FHPS in a cross-sectional analysis of the Philadelphia Neurodevelopmental Cohort (PNC). The PNC is a racially diverse community sample of 9498 youth ages 8-21 years old, of whom 8928 completed the Family Interview for Genetic Studies to determine FHPS status. Polygenic risk score for schizophrenia (PRSS) was available for a subsample of 4433 European Americans. FHPS youth (n = 489) constituted 5.5% of the analytic sample. After adjusting for environmental risk factors (sociodemographic variables and traumatic stressful events), FHPS youth had lower functioning on the Children's Global Assessment Scale and elevated psychosis spectrum, mood, externalizing, and fear symptoms compared to non-FHPS youth (all p < .001). In the European-American subsample, FHPS status was associated with poorer functioning and greater symptom burden in all four psychopathology domains (all p < .001), even after covarying for PRSS. Thus, ascertaining FHPS is important because it is uniquely associated with symptoms and functional impairment in community youth beyond PRS-S and the environmental risk factors we investigated. Future research identifying environmental causes of FHPS-associated impairment could inform the development of interventions for the broad array of symptoms observed in FHPS youth.
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