Evidence map›Paper›PMID 31883822›Full record

ArticleNeuroscience2020

Dopamine Evokes a Trace Amine Receptor-dependent Inward Current that is Regulated by AMP Kinase in Substantia Nigra Dopamine Neurons.

Wei Yang, Adam C Munhall, Steven W Johnson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Effect of Combined Levothyroxine (L-TInternational journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Wei YangDepartment of Neurology, Oregon Health & Science University, Portland, OR 97239, USA.
Adam C MunhallVeterans Affairs Portland Health Care System, Portland, OR 97239, USA.
Steven W JohnsonDepartment of Neurology, Oregon Health & Science University, Portland, OR 97239, USA; Veterans Affairs Portland Health Care System, Portland, OR 97239, USA. Electronic address: johnsost@ohsu.edu.
Oregon Health & Science University · USVA Portland Health Care System · US

Funding

Regulation of VTA dopamine neurons by AMP kinaseR01DA038208 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI JOHNSON, STEVEN WILLIAM · 2014 to 2017
$1.3M
Regulation of VTA dopamine neurons by AMP kinaseI01BX002525 · VA · PORTLAND VA MEDICAL CENTER · PI JOHNSON, STEVEN WILLIAM · 2015 to 2018
–
BLRD VA I01 BX002525NIDA NIH HHS R01 DA038208
6 · The paper itself

Abstract

We reported recently that activators of AMP-activated protein kinase (AMPK) slow the rundown of current evoked by the D2 autoreceptor agonist quinpirole in rat substantia nigra compacta (SNC) dopamine neurons. The present study examined the effect of AMPK on current generated by dopamine, which unlike quinpirole, is a substrate for the dopamine transporter (DAT). Using whole-cell patch-clamp, we constructed current-voltage (I-V) plots while superfusing brain slices with dopamine (100 μM) for 25 min. Two minutes after starting superfusion, dopamine evoked a peak current with an average slope conductance of 0.97 nS and an estimated reversal potential (E

Indexed as

AMP-Activated Protein KinasesAnimalsBenzamidesBenzazepinesBenzimidazolesBiphenyl CompoundsDopamineDopamine D2 Receptor AntagonistsDopamine Plasma Membrane Transport ProteinsDopaminergic NeuronsNaphthalimidesPars CompactaPatch-Clamp TechniquesPiperazinesPyrazolesPyrimidines1-(2 (diphenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrileAMP-Activated Protein KinasesBenzamidesBenzazepinesBenzimidazolesBiphenyl CompoundsDopamineDopamine D2 Receptor AntagonistsDopamine Plasma Membrane Transport ProteinsdorsomorphinecopipamN-(3-ethoxyphenyl)-4-pyrrolidin-1-yl-3-trifluoromethylbenzamideNaphthalimidesPiperazinesPyrazolesPyrimidinesPyronesPyrrolidinesReceptors, G-Protein-CoupledSTO 609SulpirideThiophenesTrace Amine-Associated ReceptorsAMP kinasebrain slicedopaminedopamine transporterpatch-clamptrace amine

Identifiers

PMID31883822
PMCPMC6997047
OpenAlexW2996896062

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.