Evidence map›Paper›PMID 31883795›Full record

ArticleCell2020

Positioning Heterochromatin at the Nuclear Periphery Suppresses Histone Turnover to Promote Epigenetic Inheritance.

Sahana Holla, Jothy Dhakshnamoorthy, H Diego Folco, Vanivilasini Balachandran, Hua Xiao, Ling-Ling Sun, David Wheeler, Martin Zofall, Shiv I S Grewal

Open access · greenAbstract read
In one paragraph

Article in Cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 108 citations in OpenAlex.

  1. Integrative modeling of the genome structure and dynamics in fission yeast.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  9. Interrogating the regulatory epigenome of cellular senescence.Cellular and molecular life sciences : CMLS · 2025
    Review
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  15. Review
  16. Clr4Nature communications · 2024
    Article
  17. Article
  18. Review
  19. Article
  20. Article

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Sahana HollaLaboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Jothy DhakshnamoorthyLaboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
H Diego FolcoLaboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Vanivilasini BalachandranLaboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Hua XiaoLaboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Ling-Ling SunLaboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
David WheelerLaboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Martin ZofallLaboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Shiv I S GrewalLaboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: grewals@mail.nih.gov.
National Institutes of Health · USNational Cancer Institute · US

Funding

RNAi and Epigenetic Control of Higher-Order Chromatin AssemblyZIABC010523 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GREWAL, SHIVINDER S · 2009 to 2025
$28.1M
Roles of Chromatin-modifying Factors in Epigenetic Control of the GenomeZIABC011208 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GREWAL, SHIVINDER S · 2009 to 2025
$28.1M
RNAi and Epigenetic Control of Higher-Order Chromatin AssemblyZ01BC010523 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GREWAL, SHIVINDER S · 2003 to 2008
$4.4M
Intramural NIH HHS Z01 BC010523Intramural NIH HHS Z99 CA999999
6 · The paper itself

Abstract

In eukaryotes, heterochromatin is generally located at the nuclear periphery. This study investigates the biological significance of perinuclear positioning for heterochromatin maintenance and gene silencing. We identify the nuclear rim protein Amo1

Indexed as

Cell Cycle ProteinsCell NucleusChromosomal Proteins, Non-HistoneEpigenesis, GeneticEpigenetic RepressionGene SilencingHeredityHeterochromatinHistonesMethylationNuclear ProteinsSchizosaccharomycesSchizosaccharomyces pombe ProteinsCell Cycle ProteinsChromosomal Proteins, Non-HistoneHeterochromatinHistonesNuclear ProteinsSchizosaccharomyces pombe Proteinschromatinepigenetic inheritancegene regulationheterochromatinheterochromatin spreadinghistone methylationnuclear organizationnuclear periphery

Identifiers

PMID31883795
PMCPMC7102895
OpenAlexW2997256491

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.