Evidence map›Paper›PMID 31883792›Full record

ArticleCell2020

Structural Basis of Human KCNQ1 Modulation and Gating.

Ji Sun, Roderick MacKinnon

Open access · greenAbstract read
In one paragraph

Article in Cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 192 papers.

0numbers the graph read from it
0cells of the map it votes in
192citing papers in PubMed
23.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

192 citing papers in PubMed, 302 citations in OpenAlex.

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  11. Cannabidiol inhibits both human KActa pharmacologica Sinica · 2026
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  12. PIPNature communications · 2026
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  18. Coupling of functionality to trafficking of KCNQ2/3 potassium channels at the axon initial segment.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  19. Article
  20. Article

132 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Ji SunLaboratory of Molecular Neurobiology and Biophysics and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
Roderick MacKinnonLaboratory of Molecular Neurobiology and Biophysics and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. Electronic address: mackinn@rockefeller.edu.
Howard Hughes Medical Institute · USRockefeller University · US

Funding

Voltage-Dependent Ion Channel GatingR01GM043949 · NIGMS · ROCKEFELLER UNIVERSITY · PI MACKINNON, RODERICK · 1990 to 2024
$10.1M
Structural and Pharmacological Study of the KCNQ1/KCNE1 Potassium Channel ComplexR00HL143037 · NHLBI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI SUN, JI · 2020 to 2022
$747k
Structural and Pharmacological Study of the KCNQ1/KCNE1 Potassium Channel ComplexK99HL143037 · NHLBI · ROCKEFELLER UNIVERSITY · PI SUN, JI · 2018 to 2019
$246k
Howard Hughes Medical InstituteNHLBI NIH HHS K99 HL143037NHLBI NIH HHS R00 HL143037NIGMS NIH HHS R01 GM043949
6 · The paper itself

Abstract

KCNQ1, also known as Kv7.1, is a voltage-dependent K

Indexed as

Cryoelectron MicroscopyHumansIon Channel GatingKCNQ1 Potassium ChannelMembrane PotentialsPatch-Clamp TechniquesPhosphatidylinositol 4,5-DiphosphatePotassium Channels, Voltage-GatedKCNE3 protein, humanKCNQ1 Potassium ChannelKCNQ1 protein, humanPhosphatidylinositol 4,5-DiphosphatePotassium Channels, Voltage-Gatedion channel gatingion channel modulationK channel beta-subunitKCNE3KCNQ1long-QT syndromesPIP2

Identifiers

PMID31883792
PMCPMC7083075
OpenAlexW2997765786

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.