Evidence map›Paper›PMID 31883742›Full record

ArticleJournal of neuroscience methods2020

Counted cycles method to measure the block inception time of kiloHertz frequency mammalian motor nerve block.

N Bhadra, E L Foldes, M R Gerges, D M Ackermann, N Bhadra, K L Kilgore

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroscience methods, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

N BhadraMetroHealth Medical Center, Cleveland, OH, USA. Electronic address: nxb26@case.edu.
E L FoldesArizona State University, Tempe, AZ, USA.
M R GergesCleveland Clinic Lerner College of Medicine, Cleveland, OH, USA.
D M AckermannPresidio Medical, Inc., AZ, USA.
N BhadraCase Western Reserve University, Cleveland, OH, USA.
K L KilgoreMetroHealth Medical Center, Cleveland, OH, USA; Case Western Reserve University, Cleveland, OH, USA; Louis Stokes VA Medical Center, Cleveland, OH, USA.
MetroHealth · USArizona State University · USCleveland Clinic Lerner College of Medicine · US

Funding

A Novel Waveform for Electrical Nerve Conduction BlockR01EB002091 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI KILGORE, KEVIN L. · 2003 to 2010
$2.6M
Combined No Onset Waveform for KiloHertz Frequency Alternating Current Nerve BlockR01EB024860 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI BHADRA, NILOY · 2017 to 2020
$2.1M
NIBIB NIH HHS R01 EB002091NIBIB NIH HHS R01 EB024860
6 · The paper itself

Abstract

backgroundKilohertz frequency alternating currents (KHFAC) produce rapid nerve conduction block of mammalian peripheral nerves and have potential clinical applications in reducing nerve hyperactivity. However, there are no experimental measurements of the block inception time (BIT) for the complete block of mammalian motor axons, i.e. the time from the start of delivery of the KHFAC to the axons reaching a fully blocked state. NEW

methodA "counted cycles" method (CCM) was designed to exploit characteristics of the onset response, which is typical of KHFAC block, to measure the BIT with a millisecond time resolution. Randomized and repeated experiments were conducted in an in-vivo rodent model, using trains of KHFAC over a range of complete cycle counts at three frequencies (10, 20, and 40 kHz).

resultsComplete motor nerve conduction block was obtained in the rat sciatic nerve (N = 4) with an average BIT range of 5 ms-10 ms. The fastest BIT measured was 2.5 ms-5 ms. There was no statistical difference between the block inception times for the three frequencies tested. COMPARISON WITH EXISTING

methodsThere are no comparable methods to measure the KHFAC BIT.

conclusionThe KHFAC BIT is faster than previously estimated. KHFAC motor nerve block is established in milliseconds. These results may assist in the design of methods to eliminate the onset response produced by KHFAC nerve block.

Indexed as

Nerve BlockNeural ConductionAnimalsAxonsElectric StimulationRatsSciatic NerveBlock onset responseElectrical nerve conduction blockKilohertz frequency alternating currentMammalian peripheral nerveNerve block inception time

Identifiers

PMID31883742
PMCPMC6999616
OpenAlexW2997618990

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.