ArticleJournal of food and drug analysis2020
In vitro and in vivo evaluation of the neuroprotective activity of Uncaria hirsuta Haviland.
Article in Journal of food and drug analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- New Monoterpenoid Indole Alkaloids as Potential Neuroprotective Agents fromMolecules (Basel, Switzerland) · 2026Article
- Anti-ageing and attenuating cognitive declines of Dicliptera chinensis extracts and purified compounds in vitro and in scopolamine-induced cognitive dysfunction mice.Botanical studies · 2025Article
- Article
- Endophytic fungi: a potential source for drugs against central nervous system disorders.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Review
- Neurotherapy of Yi-Gan-San, a Traditional Herbal Medicine, in an Alzheimer's Disease Model ofPlants (Basel, Switzerland) · 2022Article
- Vitisin A, a Resveratrol Tetramer, Improves Scopolamine-Induced Impaired Learning and Memory Functions in Amnesiac ICR Mice.Biomedicines · 2022Article
- Review
- Pharmacological Potentiality of Bioactive Flavonoid against Ketamine Induced Cell Death of PC 12 Cell Lines: An In Vitro Study.Antioxidants (Basel, Switzerland) · 2021Article
- Neuroprotective Effects of Coffee Bioactive Compounds: A Review.International journal of molecular sciences · 2020Review
- The Great Healing Potential Hidden in Plant Preparations of Antioxidant Properties: A Return to Nature?Oxidative medicine and cellular longevity · 2020Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The incidence of neurodegeneration leading to the conditions such as Alzheimer's and Parkinson's diseases are on the increase, they require the approaches that focus on protection prevention rather than treatment. Plants are rich sources of many compounds which possess medicinal properties. We sought to investigate the neuroprotective effects of Uncariahirsuta and its compounds on d-galactose-induced stress in BALB/c mice as well as 6-hydroxydopamine (6-OHDA)-induced stress in mouse nerve growth factor (mNGF)-differentiated PC12 cells. Our results demonstrate that the 95% ethanol extract of U. hirsuta reversed the d-galactose-induced learning and memory dysfunctions and decreased the malodialdehyde levels. Furthermore, the isolated compounds, 5β-carboxystrictosidine (1) and chlorogenic acid (2), protected mNGF-differentiated PC12 cells against toxicity induced by 6-OHDA by acting as antiapoptotic agents. The 50% inhibitory concentration (IC
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