ArticleBipolar disorders2020
White matter microstructure in youth with and at risk for bipolar disorder.
Article in Bipolar disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Structural connectivity associated with familial risk for mental illness: A meta-analysis of diffusion tensor imaging studies in relatives of patients with severe mental disorders.Human brain mapping · 2022Pooled it
- The uncinate fasciculus in individuals with and at risk for bipolar disorder: A meta-analysis.Journal of affective disorders · 2022Pooled it
- White Matter Microstructure in Individuals With and At Risk for Bipolar Disorder: Evidence for an Endophenotype From a Voxel-Based Meta-analysis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Pooled it
- Mapping Structural Neuroimaging Trajectories in Bipolar Disorder: Neurobiological and Clinical Implications.Biological psychiatry · 2025Review
- Distinguished Frontal White Matter Abnormalities Between Psychotic and Nonpsychotic Bipolar Disorders in a Pilot Study.Brain sciences · 2025Article
- Underlying biological mechanisms of emotion dysregulation in bipolar disorder.Frontiers in psychiatry · 2025Review
- Improving the diagnosis of bipolar disorder through machine learning - when is the time right?Neuroscience applied · 2025Article
- Cerebellar morphological differences and associations with extrinsic factors in bipolar disorder type I.Journal of affective disorders · 2023Article
- Association of polygenic risk for bipolar disorder with grey matter structure and white matter integrity in youth.Translational psychiatry · 2023Article
- Disrupted white matter microstructure correlates with impulsivity in children and adolescents with bipolar disorder.Journal of psychiatric research · 2023Article
- Thalamic Connectivity System Across Psychiatric Disorders: Current Status and Clinical Implications.Biological psychiatry global open science · 2022Review
- White matter integrity in adolescent irritability: A preliminary study.Psychiatry research. Neuroimaging · 2022Article
- Focal white matter microstructural alteration after anthracycline-based systemic treatment in long-term breast cancer survivors: a structural magnetic resonance imaging study.Brain imaging and behavior · 2022Article
- Multimodal Magnetic Resonance Imaging Reveals Aberrant Brain Age Trajectory During Youth in Schizophrenia Patients.Frontiers in aging neuroscience · 2022Article
- Differentiating white matter measures that protect against vs. predispose to bipolar disorder and other psychopathology in at-risk youth.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Evaluating endophenotypes for bipolar disorder.International journal of bipolar disorders · 2021Review
- Integrity of the uncinate fasciculus is associated with the onset of bipolar disorder: a 6-year followed-up study.Translational psychiatry · 2021Article
- Comparison of White Matter Structure of Drug-Naïve Patients With Bipolar Disorder and Major Depressive Disorder Using Diffusion Tensor Tractography.Frontiers in psychiatry · 2021Article
- White matter microstructure in youth with and at risk for bipolar disorder.Bipolar disorders · 2020Article
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7 authors at 2 institutions in 1 country.
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Abstract
objectivesBipolar disorder (BD) and familial risk for BD have been associated with aberrant white matter (WM) microstructure in the corpus callosum and fronto-limbic pathways. These abnormalities might constitute trait or state marker and have been suggested to result from aberrant maturation and to relate to difficulties in emotion regulation.
methodsTo determine whether WM alterations represent a trait, disease or resilience marker, we compared youth at risk for BD (n = 36 first-degree relatives, REL) to youth with BD (n = 36) and healthy volunteers (n = 36, HV) using diffusion tensor imaging.
resultsIndividuals with BD and REL did not differ from each other in WM microstructure and, compared to HV, showed similar aberrations in the superior corona radiata (SCR)/corticospinal tract (CST) and the body of the corpus callosum. WM microstructure of the anterior CC showed reduced age-related in-creases in BD compared to REL and HV. Further, individuals with BD and REL showed in-creased difficulties in emotion regulation, which were associated with the microstructure of the anterior thalamic radiation. DISCUSSION: Alterations in the SCR/CST and the body of the corpus callosum appear to represent a trait marker of BD, whereas changes in other WM tracts seem to be a disease state marker. Our findings also support the role of aberrant developmental trajectories of WM microstructure in the risk architecture of BD, although longitudinal studies are needed to confirm this association. Finally, our findings show the relevance of WM microstructure for difficulties in emotion regulation-a core characteristic of BD.
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