Evidence map›Paper›PMID 31883393›Full record

ArticlePhotochemistry and photobiology2020

Local and Systemic Antitumor Effects of Photo-activatable Paclitaxel Prodrug on Rat Breast Tumor Models.

Bharathiraja Subramaniyan, Pallavi Rajaputra, Luong Nguyen, Mengjie Li, Cody J Peer, Jessica Kindrick, William D Figg, Sukyung Woo, Youngjae You

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Photochemistry and photobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bharathiraja Subramaniyan *Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK.
Pallavi Rajaputra *Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK.
Luong NguyenDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK.
Mengjie LiDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK.
Cody J PeerClinical Pharmacology Program, National Cancer Institute, NIH, Bethesda, MD.
Jessica KindrickClinical Pharmacology Program, National Cancer Institute, NIH, Bethesda, MD.
William D FiggClinical Pharmacology Program, National Cancer Institute, NIH, Bethesda, MD.
Sukyung WooDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK.
Youngjae YouDepartment of Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY.ORCID 0000-0003-0835-464X

Funding

Using Clinical Pharmacology Principles to Develop New Anticancer TherapiesZICSC006537 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI FIGG, WILLIAM DOUGLAS · 2009 to 2025
$14.4M
Site Specific Drug Delivery with Light-responsive Conjugates for Photo-biomodulationR01GM113940 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Youngjae You · 2015 to 2026
$3.0M
NIGMS NIH HHS R01 GM113940NIGMS NIH HHS R01GM113940
6 · The paper itself

Abstract

We demonstrated that a large primary and a small untreated distant breast cancer could be controlled by local treatment with our light-activatable paclitaxel (PTX) prodrug. We hypothesized that the treated tumor would be damaged by the combinational effects of photodynamic therapy (PDT) and locally released PTX and that the distant tumor would be suppressed by systemic antitumor effects. Syngeneic rat breast cancer models (single- and two-tumor models) were established on Fischer 344 rats by subcutaneous injection of MAT B III cells. The rats were injected with PTX prodrug (dose: 1 umole kg

Indexed as

AnimalsAntineoplastic Agents, PhytogenicBreast NeoplasmsDisease Models, AnimalFemaleHumansPaclitaxelPhotochemotherapyProdrugsRatsRats, Inbred F344Antineoplastic Agents, PhytogenicPaclitaxelProdrugs

Identifiers

PMID31883393
PMCPMC8043141

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.