Trial reportEuropean heart journal2020
Sex associations and computed tomography coronary angiography-guided management in patients with stable chest pain.
Trial report in European heart journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- SCCT 2021 Expert Consensus Document on Coronary Computed Tomographic Angiography: A Report of the Society of Cardiovascular Computed Tomography.Journal of cardiovascular computed tomographyGuideline
- Sex Differences in Computed Tomography Coronary Stenosis Severity Versus Flow Impairment and Impact on Revascularization, Clinical Events and Health Care Costs: A FORECAST Substudy.Journal of the American Heart Association · 2025Trial
- Comparative effectiveness of initial computed tomography and invasive coronary angiography in women and men with stable chest pain and suspected coronary artery disease: multicentre randomised trial.BMJ (Clinical research ed.) · 2022Trial
- Validation of European Society of Cardiology pre-test probabilities for obstructive coronary artery disease in suspected stable angina.European heart journal. Quality of care & clinical outcomes · 2020Trial
- Direct access CT coronary angiography in patients referred with suspected cardiac chest pain: a novel patient pathway.Open heart · 2026Article
- Self-care needs of patients with coronary heart disease in Islamabad, Pakistan: cohort study protocol.BMJ public health · 2026Article
- Prognostic value of myocardial flow reserve measured with CZT cardiac-dedicated SPECT low-dose dynamic myocardial perfusion imaging in patients with INOCA.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Prognostic value of combined coronary CT angiography and myocardial perfusion imaging in women and men.European heart journal. Cardiovascular Imaging · 2023Article
- Advanced Cardiac Imaging and Women's Chest Pain: A Question of Gender.Diagnostics (Basel, Switzerland) · 2023Review
- Great Debate: Computed tomography coronary angiography should be the initial diagnostic test in suspected angina.European heart journal · 2023Article
- Reappraising Ischemic Heart Disease in Women.Reviews in cardiovascular medicine · 2023Review
- Coronary Arterial Function and Disease in Women With No Obstructive Coronary Arteries.Circulation research · 2022Review
- Coronary Artery Disease in Women: A Comprehensive Appraisal.Journal of clinical medicine · 2021Review
- Sex-based inequalities in contemporary UK hospital management of stable chest pain.Open heart · 2021Article
- Doppler Echocardiography Assessment of Coronary Microvascular Function in Patients With Angina and No Obstructive Coronary Artery Disease.Frontiers in cardiovascular medicine · 2021Review
- Diversity is richness: why data reporting according to sex, age, and ethnicity matters.European heart journal · 2020Article
- Coronary microvascular disease: the next frontier for Cardiovascular Research.Cardiovascular research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
Abstract
aimsThe relative benefits of computed tomography coronary angiography (CTCA)-guided management in women and men with suspected angina due to coronary heart disease (CHD) are uncertain. METHODS AND
resultsIn this post hoc analysis of an open-label parallel-group multicentre trial, we recruited 4146 patients referred for assessment of suspected angina from 12 cardiology clinics across the UK. We randomly assigned (1:1) participants to standard care alone or standard care plus CTCA. Fewer women had typical chest pain symptoms (n = 582, 32.0%) when compared with men (n = 880, 37.9%; P < 0.001). Amongst the CTCA-guided group, more women had normal coronary arteries [386 (49.6%) vs. 263 (26.2%)] and less obstructive CHD [105 (11.5%) vs. 347 (29.8%)]. A CTCA-guided strategy resulted in more women than men being reclassified as not having CHD {19.2% vs. 13.1%; absolute risk difference, 5.7 [95% confidence interval (CI): 2.7-8.7, P < 0.001]} or having angina due to CHD [15.0% vs. 9.0%; absolute risk difference, 5.6 (2.3-8.9, P = 0.001)]. After a median of 4.8 years follow-up, CTCA-guided management was associated with similar reductions in the risk of CHD death or non-fatal myocardial infarction in women [hazard ratio (HR) 0.50, 95% CI 0.24-1.04], and men (HR 0.63, 95% CI 0.42-0.95; Pinteraction = 0.572).
conclusionFollowing the addition of CTCA, women were more likely to be found to have normal coronary arteries than men. This led to more women being reclassified as not having CHD, resulting in more downstream tests and treatments being cancelled. There were similar prognostic benefits of CTCA for women and men.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.