ArticlePediatric obesity2020
Associations of maternal caffeine intake during pregnancy with abdominal and liver fat deposition in childhood.
Article in Pediatric obesity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- An Evaluation of Food and Nutrient Intake among Pregnant Women in The Netherlands: A Systematic Review.Nutrients · 2023Pooled it
- Pregnancy and Caffeine Metabolism: Updated Insights and Implications for Maternal-Fetal Health.Nutrients · 2025Review
- Review
- Association of Maternal Caffeine Consumption During Pregnancy With Child Growth.JAMA network open · 2022Article
- Maternal caffeine intake and DNA methylation in newborn cord blood.The American journal of clinical nutrition · 2022Article
- Caffeine in liver diseases: Pharmacology and toxicology.Frontiers in pharmacology · 2022Review
- Maternal First-Trimester Cow-Milk Intake Is Positively Associated with Childhood General and Abdominal Visceral Fat Mass and Lean Mass but Not with Other Cardiometabolic Risk Factors at the Age of 10 Years.The Journal of nutrition · 2021Article
- Association Between Maternal Caffeine Consumption and Metabolism and Neonatal Anthropometry: A Secondary Analysis of the NICHD Fetal Growth Studies-Singletons.JAMA network open · 2021Article
- Associations of maternal caffeine intake during pregnancy with abdominal and liver fat deposition in childhood.Pediatric obesity · 2020Article
- Caffeine Intake During Pregnancy and Risk of Childhood Obesity: A Systematic Review.International journal of MCH and AIDS · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMaternal caffeine intake during pregnancy is associated with an increased risk of childhood obesity. Studies in adults suggest that caffeine intake might also directly affect visceral and liver fat deposition, which are strong risk factors for cardio-metabolic disease.
objectiveTo assess the associations of maternal caffeine intake during pregnancy with childhood general, abdominal, and liver fat mass at 10 years of age.
methodsIn a population-based cohort from early pregnancy onwards among 4770 mothers and children, we assessed maternal caffeine intake during pregnancy and childhood fat mass at age 10 years.
resultsCompared with children whose mothers consumed <2 units of caffeine per day during pregnancy, those whose mothers consumed 4-5.9 and ≥6 units of caffeine per day had a higher body mass index, total body fat mass index, android/gynoid fat mass ratio, and abdominal subcutaneous and visceral fat mass indices. Children whose mothers consumed 4-5.9 units of caffeine per day had a higher liver fat fraction. The associations with abdominal visceral fat and liver fat persisted after taking childhood total body fat mass into account.
conclusionsHigh maternal caffeine intake during pregnancy was associated with higher childhood body mass index, total body fat, abdominal visceral fat, and liver fat. The associations with childhood abdominal visceral fat and liver fat fraction were independent of childhood total body fat. This suggests differential fat accumulation in these depots, which may increase susceptibility to cardio-metabolic disease in later life.
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