Evidence map›Paper›PMID 31883169›Full record

ArticleEuropean journal of neurology2020

Anaemia at admission is associated with poor clinical outcome in cerebral venous thrombosis.

S M Silvis, E Reinstra, S Hiltunen, E Lindgren, M R Heldner, M Mansour, M Ghiasian, K Jood, S M Zuurbier, A E Groot and 7 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Observational
  4. Review
  5. Article
  6. Review
  7. Cerebrovascular Complications of Anemia.Current neurology and neuroscience reports · 2021
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 7 countries.

S M SilvisDepartment of Neurology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0001-7633-2675
E ReinstraDepartment of Neurology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
S HiltunenDepartment of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
E LindgrenDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
M R HeldnerDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0002-3594-2159
M MansourSina Hospital, Hamadan University of Medical Science, Hamadan, Iran.
M GhiasianSina Hospital, Hamadan University of Medical Science, Hamadan, Iran.
K JoodDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
S M ZuurbierDepartment of Neurology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
A E GrootDepartment of Neurology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
M ArnoldDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
M A BarbozaNeurosciences Department, Hospital Dr R.A. Calderón Guardia, CCSS, San José, Costa Rica.
A ArauzNational Institute of Neurology and Neurosurgery Manuel Velasco Suarez, Mexico City, Mexico.
J PutaalaDepartment of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
T TatlisumakDepartment of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
J M CoutinhoDepartment of Neurology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
International CVT Consortium
Amsterdam Neuroscience · NLUniversity of Helsinki · FIHamedan University of Medical Sciences · IRSahlgrenska University Hospital · SEUniversity of Bern · CHCosta Rican Department of Social Security · CRInstituto Nacional de Neurología y Neurocirugía · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeAnaemia is associated with poor clinical outcome after ischaemic and haemorrhagic stroke. The association between anaemia and outcome in patients with cerebral venous thrombosis (CVT) was examined.

methodsConsecutive adult patients with CVT were included from seven centres. Anaemia at admission was scored according to World Health Organization definitions. Poor clinical outcome was defined as a modified Rankin Scale score 3-6 at last follow-up. A multiple imputation procedure was applied for handling missing data in the multivariable analysis. Using binary logistic regression analysis, adjustments were made for age, sex, cancer and centre of recruitment (model 1). In a secondary analysis, adjustments were additionally made for coma, intracerebral haemorrhage, non-haemorrhagic lesion and deep venous system thrombosis (model 2). In a sensitivity analysis, patients with cancer were excluded.

resultsData for 952 patients with CVT were included, 22% of whom had anaemia at admission. Patients with anaemia more often had a history of cancer (17% vs. 7%, P < 0.001) than patients without anaemia. Poor clinical outcome (21% vs. 11%, P < 0.001) and mortality (11% vs. 6%, P = 0.07) were more common amongst patients with anaemia. After adjustment, anaemia at admission increased the risk of poor outcome [adjusted odds ratio (aOR) 2.4, 95% confidence interval (CI) 1.5-3.7, model 1]. Model 2 revealed comparable results (aOR 1.9, 95% CI 1.2-3.2), as did the sensitivity analysis excluding patients with cancer (aOR 2.3, 95% CI 1.3-3.8, model 1).

conclusionThe risk of poor clinical outcome is doubled in CVT patients presenting with anaemia at admission.

Indexed as

AdultAnemiaFemaleHospitalizationHumansIntracranial ThrombosisMaleMiddle AgedModels, TheoreticalPrognosisRetrospective StudiesVenous Thrombosisanaemiacerebral venous thrombosisprognosis

Identifiers

PMID31883169
PMCPMC7155011
OpenAlexW2997482504

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.