Evidence map›Paper›PMID 31883044›Full record

Trial reportArchives of gynecology and obstetrics2020

Cross-linked hyaluronan gel to improve pregnancy rate of women patients with moderate to severe intrauterine adhesion treated with IVF: a randomized controlled trial.

Xiaoyan Mao, Yu Tao, Renfei Cai, Jie Zhang, Hongyuan Gao, Qiuju Chen, Yanping Kuang, Shaozhen Zhang

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Archives of gynecology and obstetrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Biomaterials Empowering in New Era of Women's Healthcare System.Reproductive sciences (Thousand Oaks, Calif.) · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Xiaoyan MaoDepartment of Assisted Reproduction, The Ninth People's Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yu TaoDepartment of Assisted Reproduction, The Ninth People's Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Renfei CaiDepartment of Assisted Reproduction, The Ninth People's Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jie ZhangDepartment of Assisted Reproduction, The Ninth People's Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hongyuan GaoDepartment of Assisted Reproduction, The Ninth People's Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Qiuju ChenDepartment of Assisted Reproduction, The Ninth People's Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yanping KuangDepartment of Assisted Reproduction, The Ninth People's Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shaozhen ZhangDepartment of Assisted Reproduction, The Ninth People's Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai, China. 15001867500@163.com.ORCID http://orcid.org/0000-0002-7331-6386
Shanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate whether the cross-linked hyaluronan (cHA) gel can improve the clinical pregnancy rate of patients with moderate to severe intrauterine adhesion (IUA) who underwent operative hysteroscopy followed by embryo transfer.

methodsWomen with moderate to severe IUA desiring to undergo embryo transfer were recruited in this randomized controlled trial. The patients were randomized on the day of receiving hysteroscopy. The control group received standard hysteroscopy, while cHA gel was applied to the treatment group at the end of hysteroscopy and 5-7 days after operation. All patients were expected to undergo in vitro fertilization (IVF)/intracytoplasmic sperm injection and frozen-thawed embryo transfer (FET).

resultsA total of 306 patients were enrolled in this study, of which 202 were assigned to the treatment group and 104 to the control group. Both the clinical pregnancy rate (26.3% [49/186] vs. 15.3% [13/85], P = 0.045), the implantation rate (17.7% [57/322] vs. 9.8% [15/153], P = 0.025), and the endometrial thickness on the day of embryo transfer (7.97 ± 1.37 vs. 7.50 ± 0.60 mm, P < 0.001) were significantly higher in the treatment group compared to the control group. In addition, histological assessment of the paired endometrial tissues collected before and after operation revealed a relatively higher number of tubular glands after operation (15.1 ± 13.2 vs. 28.8 ± 30.4, P = 0.166).

conclusionsTo conclude, the application of cHA gel in patients with moderate to severe IUA during hysteroscopy can improve the quality of endometrium and uterine receptivity and consequently enhance the clinical pregnancy rate after IVF/CSI and FET.

Indexed as

AdultEmbryo TransferFemaleFertilization in VitroHumansHyaluronic AcidPregnancyPregnancy RateProspective StudiesTreatment OutcomeUterine DiseasesHyaluronic AcidAsherman syndromeCross-linked hyaluronan gelEmbryo transferHysteroscopyIntrauterine adhesionUterine receptivity

Identifiers

PMID31883044
OpenAlexW2997585507

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.