Evidence map›Paper›PMID 31882951›Full record

ArticleScientific reports2019

Microscale pressure measurements based on an immiscible fluid/fluid interface.

Jing Yang, Xing Duan, Andrew K Fraser, Mohammad Ikbal Choudhury, Andrew J Ewald, Rong Li, Sean X Sun

Abstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Biophysics of lumen morphogenesis.Development (Cambridge, England) · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Hydrostatic pressure as a driver of cell and tissue morphogenesis.Seminars in cell & developmental biology · 2022
    Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jing YangDepartment of Mechanical Engineering, The Johns Hopkins University, Baltimore, MD, 21218, USA.
Xing DuanCenter for Cell Dynamics, Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Andrew K FraserCenter for Cell Dynamics, Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.ORCID http://orcid.org/0000-0001-5266-6849
Mohammad Ikbal ChoudhuryDepartment of Mechanical Engineering, The Johns Hopkins University, Baltimore, MD, 21218, USA.ORCID http://orcid.org/0000-0002-3241-9813
Andrew J EwaldCenter for Cell Dynamics, Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Rong LiCenter for Cell Dynamics, Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.ORCID http://orcid.org/0000-0002-2428-6061
Sean X SunDepartment of Mechanical Engineering, The Johns Hopkins University, Baltimore, MD, 21218, USA. ssun@jhu.edu.ORCID http://orcid.org/0000-0002-9077-7088

Funding

Medical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4M
The Role of Physical Cues in Collective Cell InvasionU54CA210173 · NCI · JOHNS HOPKINS UNIVERSITY · PI WIRTZ, DENIS · 2016 to 2020
$9.9M
The Role of Hydraulic Pressure in the Osmotic Engine Model of Cell MigrationR01GM134542 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI SEAN X SUN · 2019 to 2026
$2.1M
Center for Strategic Scientific Initiatives, National Cancer Institute (NCI Center for Strategic Scientific Initiatives) U54CA210172NCI NIH HHS U54 CA210173NIGMS NIH HHS R01 GM134542NIGMS NIH HHS T32 GM136577U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01GM114674
6 · The paper itself

Abstract

A method of microscale pressure measurement based on immiscible fluid/fluid interface is proposed. This method utilizes observed curvature changes in a fluid/fluid interface, and can accurately report hydraulic pressure in fluids at length scales of 10 microns. The method is especially suited for measuring fluid pressure in micro-scale biological samples. Using this method, we probe fluid pressure build up in epithelial domes, murine mammary gland organoids embedded in hydrogel, and lumen pressure in the developing mouse embryo. Results reveal that the pressure developed across epithelial barriers is on the order of 100~300 Pa, and is modulated by ion channel activity.

Indexed as

MicrofluidicsPressureAnimalsHydrogelsMammary Glands, AnimalMiceOrganoidsSurface TensionHydrogels

Identifiers

PMID31882951
PMCPMC6934680

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.