ArticleScientific reports2019
Mesolimbic dopamine D2 receptors and neural representations of subjective value.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
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- A large-scale dataset of choice and response-time data in intertemporal choice.Scientific data · 2026Article
- Social closeness and reward sensitivity enhance corticostriatal function during experiences of shared rewards.Biological psychology · 2026Article
- Social Reward Learning Deficits and Concordant Brain Alterations in Rats Overexpressing Disrupted-in-Schizophrenia 1 (DISC1).The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A neurofunctional signature of affective arousal generalizes across valence domains and distinguishes subjective experience from autonomic reactivity.Nature communications · 2025Article
- Intra-striatal dopaminergic inter-subject covariance in social drinkers and non-treatment-seeking alcohol use disorder participants.Addiction biology · 2024Article
- Health involvement modulates physician preference in the brain during online health consultation.Scientific reports · 2024Article
- A mesocorticolimbic signature of pleasure in the human brain.Nature human behaviour · 2023Article
- Unselfish traits and social decision-making patterns characterize six populations of real-world extraordinary altruists.Nature communications · 2023Article
- Neural Correlates Underlying Social-Cue-Induced Value Change.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Decision neuroscience and neuroeconomics: Recent progress and ongoing challenges.Wiley interdisciplinary reviews. Cognitive science · 2022Review
- Brain opioid segments and striatal patterns of dopamine release induced by naloxone and morphine.Human brain mapping · 2022Article
- From exploration to exploitation: a shifting mental mode in late life development.Trends in cognitive sciences · 2021Review
- Dopamine Receptor Subtypes, Physiology and Pharmacology: New Ligands and Concepts in Schizophrenia.Frontiers in pharmacology · 2020Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The process by which the value of delayed rewards is discounted varies from person to person. It has been suggested that these individual differences in subjective valuation of delayed rewards are supported by mesolimbic dopamine D2-like receptors (D2Rs) in the ventral striatum. However, no study to date has documented an association between direct measures of dopamine receptors and neural representations of subjective value in humans. Here, we examined whether individual differences in D2R availability were related to neural subjective value signals during decision making. Human participants completed a monetary delay discounting task during an fMRI scan and on a separate visit completed a PET scan with the high affinity D2R tracer [18 F]fallypride. Region-of-interest analyses revealed that D2R availability in the ventral striatum was positively correlated with subjective value-related activity in the ventromedial prefrontal cortex and midbrain but not with choice behavior. Whole-brain analyses revealed a positive correlation between ventral striatum D2R availability and subjective value-related activity in the left inferior frontal gyrus and superior insula. These findings identify a link between a direct measure of mesolimbic dopamine function and subjective value representation in humans and suggest a mechanism by which individuals vary in neural representation of discounted subjective value.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.