Evidence map›Paper›PMID 31882874›Full record

ArticleScientific reports2019

C. elegans expressing D76N β

Giulia Faravelli, Sara Raimondi, Loredana Marchese, Frederick A Partridge, Cristina Soria, P Patrizia Mangione, Diana Canetti, Michele Perni, Francesco A Aprile, Irene Zorzoli and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Human wild-type and D76N βFASEB bioAdvances · 2023
    Article
  2. Article
  3. Review
  4. Article
  5. Global Proteotoxicity Caused by Human βInternational journal of molecular sciences · 2021
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Giulia FaravelliDepartment of Molecular Medicine, Institute of Biochemistry, University of Pavia, 27100, Pavia, Italy. giulia.faravelli01@universitadipavia.it.
Sara RaimondiDepartment of Molecular Medicine, Institute of Biochemistry, University of Pavia, 27100, Pavia, Italy.
Loredana MarcheseDepartment of Molecular Medicine, Institute of Biochemistry, University of Pavia, 27100, Pavia, Italy.ORCID http://orcid.org/0000-0001-6750-6450
Frederick A PartridgeCentre for Respiratory Biology, UCL Respiratory, Division of Medicine, University College London, Gower Street, London, WC1E 6JF, United Kingdom.ORCID http://orcid.org/0000-0001-6236-4297
Cristina SoriaDepartment of Molecular Medicine, Institute of Biochemistry, University of Pavia, 27100, Pavia, Italy.
P Patrizia MangioneDepartment of Molecular Medicine, Institute of Biochemistry, University of Pavia, 27100, Pavia, Italy.
Diana CanettiWolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, University College London, London, UK.
Michele PerniCentre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.ORCID http://orcid.org/0000-0001-7593-8376
Francesco A AprileCentre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.
Irene ZorzoliDepartment of Molecular Medicine, Institute of Biochemistry, University of Pavia, 27100, Pavia, Italy.
Elia Di SchiaviInstitute of Biosciences and Bioresources (IBBR), CNR, 80131, Naples, Italy.ORCID http://orcid.org/0000-0002-8179-6666
David A LomasCentre for Respiratory Biology, UCL Respiratory, Division of Medicine, University College London, Gower Street, London, WC1E 6JF, United Kingdom.
Vittorio BellottiDepartment of Molecular Medicine, Institute of Biochemistry, University of Pavia, 27100, Pavia, Italy.ORCID http://orcid.org/0000-0002-0467-864X
David B SattelleCentre for Respiratory Biology, UCL Respiratory, Division of Medicine, University College London, Gower Street, London, WC1E 6JF, United Kingdom.
Sofia GiorgettiDepartment of Molecular Medicine, Institute of Biochemistry, University of Pavia, 27100, Pavia, Italy. s.giorgetti@unipv.it.ORCID http://orcid.org/0000-0001-9438-6511
University of Pavia · ITUniversity College London · GBUniversity of Cambridge · GBInstitute of Biosciences and Bioresources · IT

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
HSRD VA IIR 16-003Medical Research Council MR/N024842/1Medical Research Council MR/R016984/1NIH HHS P40 OD010440
6 · The paper itself

Abstract

The availability of a genetic model organism with which to study key molecular events underlying amyloidogenesis is crucial for elucidating the mechanism of the disease and the exploration of new therapeutic avenues. The natural human variant of β

Indexed as

AmyloidAmyloidosisAnimalsAnimals, Genetically Modifiedbeta 2-MicroglobulinCaenorhabditis elegansCaenorhabditis elegans ProteinsDisease Models, AnimalDrug Evaluation, PreclinicalMutation, MissensePhenotypeProtein Aggregation, PathologicalProtein FoldingAmyloidbeta 2-MicroglobulinCaenorhabditis elegans Proteins

Identifiers

PMID31882874
PMCPMC6934621
OpenAlexW2996860114

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.