Evidence map›Paper›PMID 31882854›Full record

ArticleScientific reports2019

High-fat diet-induced metabolic syndrome and oxidative stress in obese rats are ameliorated by yogurt supplementation.

Shoumen Lasker, Md Mizanur Rahman, Faisal Parvez, Mushfera Zamila, Pintu Miah, Kamrun Nahar, Fariha Kabir, Surovi Binte Sharmin, Nusrat Subhan, Gias U Ahsan and 1 more

Abstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

108 citing papers in PubMed.

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48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shoumen LaskerDepartment of Pharmaceutical Sciences, North South University, Dhaka, 1219, Bangladesh.
Md Mizanur RahmanDepartment of Pharmaceutical Sciences, North South University, Dhaka, 1219, Bangladesh.
Faisal ParvezDepartment of Pharmaceutical Sciences, North South University, Dhaka, 1219, Bangladesh.
Mushfera ZamilaDepartment of Pharmaceutical Sciences, North South University, Dhaka, 1219, Bangladesh.
Pintu MiahDepartment of Pharmaceutical Sciences, North South University, Dhaka, 1219, Bangladesh.
Kamrun NaharDepartment of Pharmaceutical Sciences, North South University, Dhaka, 1219, Bangladesh.
Fariha KabirDepartment of Pharmaceutical Sciences, North South University, Dhaka, 1219, Bangladesh.
Surovi Binte SharminDepartment of Pharmaceutical Sciences, North South University, Dhaka, 1219, Bangladesh.
Nusrat SubhanDepartment of Pharmaceutical Sciences, North South University, Dhaka, 1219, Bangladesh.
Gias U AhsanDepartment of Public Health, School of Health and Life Sciences, North South University, Dhaka, Bangladesh. gias.ahsan@northsouth.edu.
Md Ashraful AlamDepartment of Pharmaceutical Sciences, North South University, Dhaka, 1219, Bangladesh. sonaliagun@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The main objective of this experiment was to determine the effects of yogurt supplementation on fat deposition, oxidative stress, inflammation and fibrosis in the liver of rats with high-fat (HF) diet-induced obesity. Male Wistar rats were used in this study and were separated into the following four different groups: the control, control + yogurt, high fat and high fat+ yogurt groups. The high fat groups received a HF diet for eight weeks. A 5% yogurt (w/w) supplement was also provided to rats fed the HF diet. Yogurt supplementation prevented glucose intolerance and normalized liver-specific enzyme activities in the HF diet-fed rats. Yogurt supplementation also significantly reduced the levels of oxidative stress markers in the plasma and liver of HF diet-fed rats. Moreover, inflammatory cell infiltration, collagen deposition and fibrosis in the liver of HF diet-fed rats were also prevented by yogurt supplementation. Furthermore, yogurt supplementation normalized the intestinal lining and brush border in HF diet-fed rats. This study suggests that yogurt supplementation potentially represents an alternative therapy for the prevention of metabolic syndrome in HF diet-fed rats.

Indexed as

DietDiet, High-FatOxidative StressYogurtAnimalsMetabolic SyndromeObesityRats

Identifiers

PMID31882854
PMCPMC6934669

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.