ArticleScientific reports2019
Zebrafish structural development in Mueller-matrix scanning microscopy.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 31 citations in OpenAlex.
- Multiparametric Remote Investigation in the near-IR through Optical Fiber for In Situ Measurements.Sensors (Basel, Switzerland) · 2023Article
- Optical Coherence Tomography Is a Promising Tool for Zebrafish-Based Research-A Review.Bioengineering (Basel, Switzerland) · 2022Review
- Dual division of focal plane polarimeters-based collinear reflection Mueller matrix fast imaging microscope.Journal of biomedical optics · 2022Article
- Phasor map analysis to investigate Hutchinson-Gilford progeria cell under polarization-resolved optical scanning microscopy.Scientific reports · 2022Article
- Phasor approach of Mueller matrix optical scanning microscopy for biological tissue imaging.Biophysical journal · 2021Article
- Polarimetric data-based model for tissue recognition.Biomedical optics express · 2021Article
- Polarimetric imaging microscopy for advanced inspection of vegetal tissues.Scientific reports · 2021Article
- Linear diattenuation imaging of biological tissues with near infrared Mueller scanning microscopy.Biomedical optics express · 2021Article
- Circular Intensity Differential Scattering for Label-Free Chromatin Characterization: A Review for Optical Microscopy.Polymers · 2020Review
- High-resolution polarization-sensitive optical coherence tomography for zebrafish muscle imaging.Biomedical optics express · 2020Article
- Polarized Hyperspectral Microscopic Imaging for Zebrafish.Proceedings of SPIE--the International Society for Optical EngineeringArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zebrafish are powerful animal models for understanding biological processes and the molecular mechanisms involved in different human diseases. Advanced optical techniques based on fluorescence microscopy have become the main imaging method to characterize the development of these organisms at the microscopic level. However, the need for fluorescence probes and the consequent high light doses required to excite fluorophores can affect the biological process under observation including modification of metabolic function or phototoxicity. Here, without using any labels, we propose an implementation of a Mueller-matrix polarimeter into a commercial optical scanning microscope to characterize the polarimetric transformation of zebrafish preserved at different embryonic developmental stages. By combining the full polarimetric measurements with statistical analysis of the Lu and Chipman mathematical decomposition, we demonstrate that it is possible to quantify the structural changes of the biological organization of fixed zebrafish embryos and larvae at the cellular scale. This convenient implementation, with low light intensity requirement and cheap price, coupled with the quantitative nature of Mueller-matrix formalism, can pave the way for a better understanding of developmental biology, in which label-free techniques become a standard tool to study organisms.
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