ArticleScientific reports2019
Cholinergic Modulation Promotes Attentional Modulation in Primary Visual Cortex- A Modeling Study.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Acetylcholine enhances deviance detection in Hodgkin-Huxley neuronal networks.Cognitive neurodynamics · 2026Article
- Cholinergic modulation mediates attentional mechanism to enhance coherence between cortical layers in macaque V1 and V4.Scientific reports · 2025Article
- Adrenergic Modulation of Cortical Gain and Sensory Processing in the Mouse Visual Cortex.Brain sciences · 2025Article
- Visual hallucinations in Parkinson's disease: spotlight on central cholinergic dysfunction.Brain : a journal of neurology · 2025Review
- Regional cerebral cholinergic vesicular transporter correlates of visual contrast sensitivity in Parkinson's disease: Implications for visual and cognitive function.Parkinsonism & related disorders · 2025Article
- REDOX Balance in Oligodendrocytes Is Important for Zebrafish Visual System Regeneration.Antioxidants (Basel, Switzerland) · 2023Article
- Adaptive control of synaptic plasticity integrates micro- and macroscopic network function.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Computational components of visual predictive coding circuitry.Frontiers in neural circuits · 2023Review
- Role of Choline in Ocular Diseases.International journal of molecular sciences · 2021Review
- Neurochemistry of Visual Attention.Frontiers in neuroscience · 2021Review
- Article
- How Outcome Uncertainty Mediates Attention, Learning, and Decision-Making.Trends in neurosciences · 2020Review
- Dynamic coupling of whole-brain neuronal and neurotransmitter systems.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Attention in Psychology, Neuroscience, and Machine Learning.Frontiers in computational neuroscience · 2020Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Attention greatly influences sensory neural processing by enhancing firing rates of neurons that represent the attended stimuli and by modulating their tuning properties. The cholinergic system is believed to partly mediate the attention contingent improvement of cortical processing by influencing neuronal excitability, synaptic transmission and neural network characteristics. Here, we used a biophysically based model to investigate the mechanisms by which cholinergic system influences sensory information processing in the primary visual cortex (V1) layer 4C. The physiological properties and architectures of our model were inspired by experimental data and include feed-forward input from dorsal lateral geniculate nucleus that sets up orientation preference in V1 neural responses. When including a cholinergic drive, we found significant sharpening in orientation selectivity, desynchronization of LFP gamma power and spike-field coherence, decreased response variability and correlation reduction mostly by influencing intracortical interactions and by increasing inhibitory drive. Our results indicated that these effects emerged due to changes specific to the behavior of the inhibitory neurons. The behavior of our model closely resembles the effects of attention on neural activities in monkey V1. Our model suggests precise mechanisms through which cholinergic modulation may mediate the effects of attention in the visual cortex.
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