ArticleScientific reports2019
Impact of spaceflight on the murine thymus and mitigation by exposure to artificial gravity during spaceflight.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Women in space: A review of known physiological adaptations and health perspectives.Experimental physiology · 2026Review
- ibSLS as a biobank for democratizing access to multi-omics data and biospecimens from spaceflight research.Nature communications · 2026Article
- Interpretable spatial multi-omics data integration and dimensionality reduction with SpaMV.Nature communications · 2026Article
- Are we trapped on Earth: space and accelerated ageing.NPJ microgravity · 2025Review
- Interpretable spatial multi-omics data integration and dimension reduction with SpaMV.Research square · 2025Article
- Impact of microgravity and lunar gravity on murine skeletal and immune systems during space travel.Scientific reports · 2024Article
- Microbiology of human spaceflight: microbial responses to mechanical forces that impact health and habitat sustainability.Microbiology and molecular biology reviews : MMBR · 2024Review
- Review
- Microgravity's effects on miRNA-mRNA regulatory networks in a mouse model of segmental bone defects.PloS one · 2024Article
- Toward an Etiology of Spaceflight Neuroplastic Syndrome: Evolutionary Science Leads to New Hypotheses and Program Priorities.NeuroSci · 2023Article
- The Impact of Microgravity on Immunological States.ImmunoHorizons · 2023Review
- Exposure of volunteers to microgravity by dry immersion bed over 21 days results in gene expression changes and adaptation of T cells.Science advances · 2023Article
- Review
- Artificial gravity partially protects space-induced neurological deficits in Drosophila melanogaster.Cell reports · 2022Article
- Article
- Chronic Hypergravity Induces a Modification of Histone H3 Lysine 27 Trimethylation at TCRβ Locus in Murine Thymocytes.International journal of molecular sciences · 2022Article
- Impact of spaceflight and artificial gravity on sulfur metabolism in mouse liver: sulfur metabolomic and transcriptomic analysis.Scientific reports · 2021Article
- Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions.NPJ microgravity · 2021Review
- How the Immune System Deploys Creativity: Why We Can Learn From Astronauts and Cosmonauts.Frontiers in psychology · 2021Review
- An Integrative Network Science and Artificial Intelligence Drug Repurposing Approach for Muscle Atrophy in Spaceflight Microgravity.Frontiers in cell and developmental biology · 2021Article
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Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The environment experienced during spaceflight may impact the immune system and the thymus appears to undergo atrophy during spaceflight. However, molecular aspects of this thymic atrophy remain to be elucidated. In this study, we analysed the thymi of mice on board the international space station (ISS) for approximately 1 month. Thymic size was significantly reduced after spaceflight. Notably, exposure of mice to 1 × g using centrifugation cages in the ISS significantly mitigated the reduction in thymic size. Although spaceflight caused thymic atrophy, the global thymic structure was not largely changed. However, RNA sequencing analysis of the thymus showed significantly reduced expression of cell cycle-regulating genes in two independent spaceflight samples. These reductions were partially countered by 1 × g exposure during the space flights. Thus, our data suggest that spaceflight leads to reduced proliferation of thymic cells, thereby reducing the size of the thymus, and exposure to 1 × g might alleviate the impairment of thymus homeostasis induced by spaceflight.
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