ArticleScientific reports2019
Clinical and neuroimaging disparity between Chinese and German patients with cerebral small vessel disease: a comparative study.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Large diameter hemicraniectomy does not improve long-term outcome in malignant infarction.Journal of neurology · 2023Trial
- Magnetic Resonance Imaging in Cerebral Small Vessel Disease-Related Depression: From Visual Scoring to Artificial Intelligence.CNS neuroscience & therapeutics · 2026Review
- Differences in characteristics between patients from Egypt and Germany presenting with lacunar stroke.Scientific reports · 2023Article
- Brain MRI correlations with disease burden and biomarkers in Fabry disease.Journal of neurology · 2023Article
- Cerebral small-vessel disease at high altitude: A comparison of patients from plateau and plain.Frontiers in neurology · 2023Article
- Association of Serum GFAP with Functional and Neurocognitive Outcome in Sporadic Small Vessel Disease.Biomedicines · 2022Article
- Fundus Changes Evaluated by OCTA in Patients With Cerebral Small Vessel Disease and Their Correlations: A Cross-Sectional Study.Frontiers in neurology · 2022Article
- Higher Blood Pressure is Associated with Greater White Matter Lesions and Brain Atrophy: A Systematic Review with Meta-Analysis.Journal of clinical medicine · 2021Review
- Risk factors of white matter hyperintensities in South Asian patients with transient ischemic attack and minor stroke.Neuroradiology · 2020Article
- Optical coherence tomography-based assessment of retinal vascular pathology in cerebral small vessel disease.Neurological research and practice · 2020Article
- Genetic risk impacts stroke mortality and pathogenesis in patients with ischemic stroke: a cohort study of BioBank Japan.Frontiers in neurologyArticle
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10 authors.
Funding
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Abstract
Ethnic disparity of cerebral small vessel disease (CSVD) has been reported previously but understanding of its clinical-anatomical is sparse. Two cohorts of CSVD patients from Peking University First Hospital, China and University Hospital of Ulm, Germany were retrospectively collected between 2013 and 2017. Visual rating scales and semiautomatic computer-assisted quantitative analysis were used to describe the neuroimaging features of CSVD, including lacunes, enlarged perivascular spaces, white matter changes and microbleeds. After exclusion of confounding neurological disorders, 165 out of 220 Chinese and 86 out of 98 German patients' data were analyzed. Mean age of patients was 64.0 ± 11.9 years in China and 73.9 ± 10.3 years in Germany. Cognitive deficits were more prominent in the German group, mainly in the cognitive domains of language and delayed recall. Neuroimaging comparison showed that lacunes were more common and white matter lesion load was more severe in German than Chinese patients. Spatial distribution analysis suggested that Chinese patients showed more deep and infratentorial lesions (microbleeds and lacunes), while lesions in German patients were more frequently located in the lobes or subcortical white matter. In conclusion, different age of onset and anatomical distribution of lesions exist between Chinese and German CSVD patients in the observed population.
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