Evidence map›Paper›PMID 31882594›Full record

ArticleScientific reports2019

Development and validation of an LC-MS/MS method for detection and quantification of in vivo derived metabolites of [Pyr

Duuamene Nyimanu, Richard G Kay, Petra Sulentic, Rhoda E Kuc, Philip Ambery, Lutz Jermutus, Frank Reimann, Fiona M Gribble, Joseph Cheriyan, Janet J Maguire and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. The Apelinergic System in Pregnancy.International journal of molecular sciences · 2023
    Review
  6. Article
  7. Article
  8. Review
  9. Identification of 6-Hydroxypyrimidin-4(1ACS medicinal chemistry letters · 2021
    Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Duuamene NyimanuExperimental Medicine and Immunotherapeutics, University of Cambridge, Level 6, Centre for Clinical Investigation, Box 110, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.ORCID http://orcid.org/0000-0002-6212-9518
Richard G KayMetabolic Research Laboratories, Institute of Metabolic Sciences, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
Petra SulenticExperimental Medicine and Immunotherapeutics, University of Cambridge, Level 6, Centre for Clinical Investigation, Box 110, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
Rhoda E KucExperimental Medicine and Immunotherapeutics, University of Cambridge, Level 6, Centre for Clinical Investigation, Box 110, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
Philip AmberyLate-stage Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Lutz JermutusResearch and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
Frank ReimannMetabolic Research Laboratories, Institute of Metabolic Sciences, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.ORCID http://orcid.org/0000-0001-9399-6377
Fiona M GribbleMetabolic Research Laboratories, Institute of Metabolic Sciences, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
Joseph CheriyanExperimental Medicine and Immunotherapeutics, University of Cambridge, Level 6, Centre for Clinical Investigation, Box 110, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
Janet J MaguireExperimental Medicine and Immunotherapeutics, University of Cambridge, Level 6, Centre for Clinical Investigation, Box 110, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
Anthony P DavenportExperimental Medicine and Immunotherapeutics, University of Cambridge, Level 6, Centre for Clinical Investigation, Box 110, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK. apd10@medschl.cam.ac.uk.ORCID http://orcid.org/0000-0002-2096-3117
University of Cambridge · GBAstraZeneca (Sweden) · SEAstraZeneca (United Kingdom) · GB

Funding

Cancer Research UK 27229Medical Research Council MC_UU_00014/3Medical Research Council MC_UU_00014/5Medical Research Council MC_UU_12012/3Medical Research Council MC_UU_12012/5Medical Research Council MR/M009041/1Medical Research Council MR/M024873/1Wellcome TrustWellcome Trust 106263/Z/14/Z
6 · The paper itself

Abstract

[Pyr

Indexed as

AdultApelinApelin ReceptorsChromatography, LiquidFemaleHealthy VolunteersHumansIntercellular Signaling Peptides and ProteinsMaleMiddle AgedPeptidesPlasmaProtein IsoformsReproducibility of ResultsTandem Mass SpectrometryApelinapelin-13 peptideapelin 13, Pyr(1)-Apelin ReceptorsIntercellular Signaling Peptides and ProteinsPeptidesProtein Isoforms

Identifiers

PMID31882594
PMCPMC6934825
OpenAlexW2992330275

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.