Evidence map›Paper›PMID 31882552›Full record

ArticleCancer genomics & proteomics

Therapeutic Efficacy Evaluation of Pegylated Liposome Encapsulated With Vinorelbine Plus

Yi-Chun Chien, Ying-Hsiang Chou, Wei-Hsun Wang, John Chun-Hao Chen, Wen-Shin Chang, Chia-Wen Tsai, DA-Tian Bau, Jeng-Jong Hwang

Open access · diamondAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer genomics & proteomics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yi-Chun ChienDepartment of Medical Imaging and Radiological Sciences, I-Shou University, Jiaosu Village, Kaohsiung, Taiwan, R.O.C.
Ying-Hsiang ChouDepartment of Radiation Oncology, Chung Shan Medical University Hospital, Taichung, Taiwan, R.O.C.
Wei-Hsun WangDepartment of Orthopedic Surgery, Changhua Christian Hospital, Changhua, Taiwan, R.O.C.
John Chun-Hao ChenDepartment of Radiation Oncology, Mackay Memorial Hospital, New Taipei City, Taiwan, R.O.C.
Wen-Shin ChangGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Chia-Wen TsaiGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
DA-Tian BauGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C. jjhwang@ym.edu.tw johnjjhwang@gmail.com datian@mail.cmuh.org.tw artbau2@gmail.com.
Jeng-Jong HwangDepartment of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan, R.O.C. jjhwang@ym.edu.tw johnjjhwang@gmail.com datian@mail.cmuh.org.tw artbau2@gmail.com.
China Medical University · TWChung Shan Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimIn precision therapy, liposomal encapsulated chemotherapeutic drugs have been developed to treat cancers by achieving higher drug accumulation in the tumor compared to normal tissues/organs. MATERIALS AND

methodsWe developed a novel chemoradiotherapeutic approach via nanoliposomes conjugated with vinorelbine (VNB) and

resultsPharmacokinetic results showed that the area under the curve (AUC) of PEGylated liposomes was about 17-fold higher than that of the free radioisotope. Tumor growth inhibition by

conclusionThe tumors in NOD/SCID mice bearing HT-29/tk-luc xenografts were significantly suppressed by

Indexed as

AnimalsAntineoplastic Agents, PhytogenicApoptosisCell ProliferationChemoradiotherapyColorectal NeoplasmsHumansIndium RadioisotopesLiposomesMaleMiceMice, Inbred NODMice, SCIDMultimodal ImagingPolyethylene GlycolsPositron-Emission TomographyAntineoplastic Agents, PhytogenicIndium-111Indium RadioisotopesLiposomesPolyethylene GlycolsVinorelbineBiodistributionbioluminescencecolorectal cancermicro positron emission tomographyPEG-liposomepharmacokinetics

Identifiers

PMID31882552
PMCPMC6937124
OpenAlexW2997563020

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.