Evidence map›Paper›PMID 31882546›Full record

ArticleThe Journal of biological chemistry2020

Molecular characterization of a fungal cyclophilin allergen Rhi o 2 and elucidation of antigenic determinants responsible for IgE-cross-reactivity.

Gaurab Sircar, Moumita Bhowmik, Rajat Kanti Sarkar, Nazanin Najafi, Angira Dasgupta, Margarete Focke-Tejkl, Sabine Flicker, Irene Mittermann, Rudolf Valenta, Kashinath Bhattacharya and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 21 citations in OpenAlex.

  1. IgE to cyclophilin Bet v 7 triggers mast cell activation and mediates cross-reactivity with Ara h 18 in children with seasonal allergic rhinitis.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026
    Article
  2. Review
  3. Human Monoclonal IgE Antibodies-a Major Milestone in Allergy.Current allergy and asthma reports · 2023
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Gaurab SircarDepartment of Botany, Visva-Bharati, Santiniketan 731235, India; Division of Plant Biology (Main campus), Bose Institute, 93/1 Acharya Prafulla Chandra Rd., Kolkata 700009, India. Electronic address: sircar.gaurab1@gmail.com.
Moumita BhowmikDivision of Plant Biology (Main campus), Bose Institute, 93/1 Acharya Prafulla Chandra Rd., Kolkata 700009, India.
Rajat Kanti SarkarDepartment of Botany, Visva-Bharati, Santiniketan 731235, India.
Nazanin NajafiDivision of Immunopathology, Department of Pathophysiology and Allergy Research, Medical University of Vienna, Center for Pathophysiology, Infectiology and Immunology, Währinger Gürtel 18-20, A-1090 Vienna, Austria.
Angira DasguptaDepartment of Chest Medicine, B. R. Singh Hospital and Center for Medical Education and Research, Kolkata 700014, India.
Margarete Focke-TejklDivision of Immunopathology, Department of Pathophysiology and Allergy Research, Medical University of Vienna, Center for Pathophysiology, Infectiology and Immunology, Währinger Gürtel 18-20, A-1090 Vienna, Austria.
Sabine FlickerDivision of Immunopathology, Department of Pathophysiology and Allergy Research, Medical University of Vienna, Center for Pathophysiology, Infectiology and Immunology, Währinger Gürtel 18-20, A-1090 Vienna, Austria.
Irene MittermannDivision of Immunopathology, Department of Pathophysiology and Allergy Research, Medical University of Vienna, Center for Pathophysiology, Infectiology and Immunology, Währinger Gürtel 18-20, A-1090 Vienna, Austria.
Rudolf ValentaDivision of Immunopathology, Department of Pathophysiology and Allergy Research, Medical University of Vienna, Center for Pathophysiology, Infectiology and Immunology, Währinger Gürtel 18-20, A-1090 Vienna, Austria; NRC Institute of Immunology FMBA of Russia, 115478 Moscow, Russia; Department of Clinical Immunology and Allergy, Sechenov First Moscow State Medical University, 119146 Moscow, Russian Federation.
Kashinath BhattacharyaDepartment of Botany, Visva-Bharati, Santiniketan 731235, India. Electronic address: kashinathb23@rediffmail.com.
Swati Gupta BhattacharyaDivision of Plant Biology (Main campus), Bose Institute, 93/1 Acharya Prafulla Chandra Rd., Kolkata 700009, India. Electronic address: swati@jcbose.ac.in.
Medical University of Vienna · ATVisva-Bharati University · INBose Institute · INSechenov University · RU

Funding

Austrian Science Fund FWF P 26728Austrian Science Fund FWF P 29991DBT-Wellcome Trust India Alliance IA/E/17/1/503696Wellcome Trust
6 · The paper itself

Abstract

Cyclophilins are structurally conserved pan-allergens showing extensive cross-reactivity. So far, no precise information on cross-reactive IgE-epitopes of cyclophilins is available. Here, an 18-kDa IgE-reactive cyclophilin (Rhi o 2) was purified from

Indexed as

AllergensAmino Acid SequenceConserved SequenceCross ReactionsCyclophilinsDNA, ComplementaryEpitopesFungal ProteinsHumansHypersensitivityImmunoglobulin EPeptide FragmentsRhizopusAllergensCyclophilinsDNA, ComplementaryEpitopesFungal ProteinsImmunoglobulin EPeptide Fragmentsallergenallergycyclophilinepitope mappingfungiimmunoglobulin E (IgE)Rhi o 2

Identifiers

PMID31882546
PMCPMC7049968
OpenAlexW2998428485

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.