Evidence map›Paper›PMID 31882545›Full record

ArticleThe Journal of biological chemistry2020

Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome.

Gabriella Peluso, E Tian, Loreto Abusleme, Takashi Munemasa, Taro Mukaibo, Kelly G Ten Hagen

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Dynamics of CD44Scientific reports · 2024
    Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. In vivo models of mucin biosynthesis and function.Advanced drug delivery reviews · 2022
    Review
  11. Article
  12. Mucin-Type O-GalNAc Glycosylation in Health and Disease.Advances in experimental medicine and biology · 2021
    Article
  13. Differential splicing of the lectin domain of anThe Journal of biological chemistry · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Gabriella PelusoDevelopmental Glycobiology Section, NIDCR, National Institutes of Health, Bethesda, Maryland 20892.
E TianDevelopmental Glycobiology Section, NIDCR, National Institutes of Health, Bethesda, Maryland 20892.
Loreto AbuslemeLaboratory of Oral Microbiology, Faculty of Dentistry, University of Chile, Santiago 8380544, Chile.
Takashi MunemasaSecretory Mechanisms and Dysfunctions Section, NIDCR, National Institutes of Health, Bethesda, Maryland 20892.
Taro MukaiboSecretory Mechanisms and Dysfunctions Section, NIDCR, National Institutes of Health, Bethesda, Maryland 20892.
Kelly G Ten HagenDevelopmental Glycobiology Section, NIDCR, National Institutes of Health, Bethesda, Maryland 20892 Kelly.Tenhagen@nih.gov.
National Institute of Dental and Craniofacial Research · USKyushu Dental University · JPUniversity of Chile · CL

Funding

Role of O-glycosylation in Animal DevelopmentZIADE000713 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI TEN HAGEN, KELLY G · 2009 to 2025
$30.6M
NIDCR DIR Secretory Mechanisms and Dysfunctions SectionZIADE000738 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI MELVIN, JAMES · 2011 to 2019
$14.4M
NIDCR Annual Reports - Veterinary Resources CoreZIGDE000740 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI DAVIDSON, LAUREN · 2012 to 2025
$11.7M
Role of O-glycosylation in Animal DevelopmentZ01DE000713 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI TEN HAGEN, KELLY G · 2006 to 2008
$2.0M
Intramural NIH HHS Z01 DE000713Intramural NIH HHS ZIA DE000738Intramural NIH HHS ZIG DE000740
6 · The paper itself

Abstract

The importance of the microbiome in health and its disruption in disease is continuing to be elucidated. However, the multitude of host and environmental factors that influence the microbiome are still largely unknown. Here, we examined UDP-GalNAc:polypeptide

Indexed as

AnimalsCalcinosisFemaleFibroblast Growth Factor-23GlycosylationGlycosyltransferasesHyperostosis, Cortical, CongenitalHyperphosphatemiaMaleMiceMice, Inbred C57BLMice, KnockoutMicrobiotaMucinsN-AcetylgalactosaminyltransferasesPolypeptide N-acetylgalactosaminyltransferaseFgf23 protein, mouseFibroblast Growth Factor-23GlycosyltransferasesMucinsN-AcetylgalactosaminyltransferasesPolypeptide N-acetylgalactosaminyltransferasePolysaccharidesRNA, Ribosomal, 16SboneGalnt3glycanglycosylationglycosyltransferasehyperphosphatemic familial tumoral calcinosis (HFTC)microbiomeMuc10mucinO-glycosylationpost-translational modificationsalivasalivary proteinsubmandibular gland

Identifiers

PMID31882545
PMCPMC6996895
OpenAlexW2997767664

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.