Evidence map›Paper›PMID 31882541›Full record

ArticleThe Journal of biological chemistry2020

Structural and mechanistic insights into Hsp104 function revealed by synchrotron X-ray footprinting.

Elizabeth A Sweeny, Amber Tariq, Esin Gurpinar, Michelle S Go, Matthew A Sochor, Zhong-Yuan Kan, Leland Mayne, S Walter Englander, James Shorter

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Design principles to tailor Hsp104 therapeutics.bioRxiv : the preprint server for biology · 2024
    Article
  5. Article
  6. Drivers of Hsp104 potentiation revealed by scanning mutagenesis of the middle domain.Protein science : a publication of the Protein Society · 2021
    Article
  7. Article
  8. Heat Stress Tolerance GeneFrontiers in microbiology · 2021
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Elizabeth A SweenyDepartment of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104; Biochemistry and Molecular Biophysics Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania 19104. Electronic address: esweeny@gmail.com.
Amber TariqDepartment of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Esin GurpinarDepartment of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Michelle S GoDepartment of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Matthew A SochorDepartment of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104; Biochemistry and Molecular Biophysics Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Zhong-Yuan KanDepartment of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104; Johnson Research Foundation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Leland MayneDepartment of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104; Johnson Research Foundation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
S Walter EnglanderDepartment of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104; Biochemistry and Molecular Biophysics Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania 19104; Johnson Research Foundation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
James ShorterDepartment of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104; Biochemistry and Molecular Biophysics Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania 19104. Electronic address: jshorter@pennmedicine.upenn.edu.
University of Pennsylvania · USJohnson Foundation · US

Funding

STRUCTURAL BIOLOGY TRAINING PROGRAMT32GM008275 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI WAND, A. JOSHUA · 1988 to 2018
$6.0M
Defining the mechanistic basis of a prion disaggregaseR01GM099836 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI SHORTER, JAMES · 2013 to 2024
$3.9M
Amyloid elimination by Hsp104 and substrate-optimized variantsDP2OD002177 · OD · UNIVERSITY OF PENNSYLVANIA · PI SHORTER, JAMES · 2007 to 2007
$2.4M
NIGMS NIH HHS R01 GM099836NIGMS NIH HHS T32 GM008275NIH HHS DP2 OD002177
6 · The paper itself

Abstract

Hsp104 is a hexameric AAA

Indexed as

Adenosine TriphosphateHeat-Shock ProteinsModels, MolecularProtein AggregatesProtein ConformationProtein MultimerizationSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSynchrotronsX-Raysadenosine 5'-O-(3-thiotriphosphate)Adenosine TriphosphateHeat-Shock ProteinsHsP104 protein, S cerevisiaeProtein AggregatesSaccharomyces cerevisiae ProteinsATPases associated with diverse cellular activities (AAA)disaggregaseFUSheat-shock protein (HSP)Hsp104mass spectrometry (MS)mutagenesisprotein chemical modificationTDP-43α-synuclein

Identifiers

PMID31882541
PMCPMC7008382
OpenAlexW2997105168

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.