Evidence map›Paper›PMID 31882538›Full record

ArticleThe Journal of biological chemistry2020

Recognition of 1,

Adam Z Thelen, Patrick J O'Brien

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Mechanisms of DNA repair and mutagenesis induced by acetaldehyde, acrolein, aristolochic acids, and vinyl chloride.Journal of environmental science and health. Part C, Toxicology and carcinogenesis · 2025
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Adam Z ThelenDepartment of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109-0600.
Patrick J O'BrienDepartment of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109-0600. Electronic address: pjobrien@umich.edu.
University of Michigan · US

Funding

MICHIGAN CHEMISTRY-BIOLOGY INTERFACE TRAINING PROGRAMT32GM008597 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MONTGOMERY, JOHN · 1996 to 2018
$5.0M
Protein-DNA Dynamics in Base Excision DNA RepairR01CA122254 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI O'BRIEN, PATRICK J · 2007 to 2011
$1.4M
DNA-Protein Dynamics in Base Excision DNA RepairR01GM108022 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI O'BRIEN, PATRICK J · 2013 to 2016
$1.1M
NCI NIH HHS R01 CA122254NIGMS NIH HHS R01 GM108022NIGMS NIH HHS T32 GM008597
6 · The paper itself

Abstract

The adenine, cytosine, and guanine bases of DNA are susceptible to alkylation by the aldehyde products of lipid peroxidation and by the metabolic byproducts of vinyl chloride pollutants. The resulting adducts spontaneously cyclize to form harmful etheno lesions. Cells employ a variety of DNA repair pathways to protect themselves from these pro-mutagenic modifications. Human alkyladenine DNA glycosylase (AAG) is thought to initiate base excision repair of both 1,

Indexed as

Catalytic DomainDNA GlycosylasesGuanineHumansKineticsMolecular Docking SimulationSubstrate Specificity1,(N2)-ethenoguanine3-methyladenine-DNA glycosylaseDNA GlycosylasesGuaninealkyladenine DNA glycosylasebase excision repair (BER)DNA alkylationDNA damageDNA repairenzyme kineticsethenoguaninesubstrate specificity

Identifiers

PMID31882538
PMCPMC7008384
OpenAlexW2997752382

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.